All Phenotypes Etv6<tm1.1(RUNX1,hsb5)Lvdw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Etv6^{tm1.1(RUNX1,hsb5)Lvdw}
targeted mutation 1.1, Louise van der Weyden
MGI:5284820

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6^{tm1.1(RUNX1,hsb5)Lvdw}	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	MGI:5284838
ht2	Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J	MGI:5284839
ht3	Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	MGI:5284840
cn4	Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺ TgTn(sb-T2/Onc)76Dla/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N	MGI:5284841

Allelic Composition	Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6^{tm1.1(RUNX1,hsb5)Lvdw}
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^{tm1.1(RUNX1,hsb5)Lvdw} mutation (0 available); any Etv6 mutation (142 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:174866 )

• no mice are observed after E10.5

Allelic Composition	Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^{tm1.1(RUNX1,hsb5)Lvdw} mutation (0 available); any Etv6 mutation (142 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:174866 )

• Background Sensitivity: fewer than expected mice are produced with increased C57BL/6J background contribution

Allelic Composition	Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^{tm1.1(RUNX1,hsb5)Lvdw} mutation (0 available); any Etv6 mutation (142 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leukemia incidence ( J:174866 )

• 68% of mice develop T-cell acute lymphocytic leukemia with occasional cases of acute myeloid leukemia and B-cell precursor acute lymphoblastic leukemia (BCP-ALL; 13%)

Allelic Composition	Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺ TgTn(sb-T2/Onc)76Dla/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^{tm1.1(RUNX1,hsb5)Lvdw} mutation (0 available); any Etv6 mutation (142 available)
TgTn(sb-T2/Onc)76Dla mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:174866 )

• mice exhibit increased decreased survival compared with control mice

neoplasm

increased leukemia incidence ( J:174866 )

• mice exhibit increased incidence of leukemia compared with control mice

• predominantly acute myeloid leukemia (AML; 46%) with some T cell acute lymphocytic leukemia (T-ALL; 28%) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL; 21%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:174866

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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