All Phenotypes Kcnk18<m1Ewis> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kcnk18^m1Ewis
mutation 1, Erhard Wischmeyer
MGI:5142525

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnk18^m1Ewis/Kcnk18^m1Ewis	C3HeB/FeJ-Kcnk18^m1Ewis	MGI:5142528

Allelic Composition	Kcnk18^m1Ewis/Kcnk18^m1Ewis
Genetic Background	C3HeB/FeJ-Kcnk18^m1Ewis

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk18^m1Ewis mutation (0 available); any Kcnk18 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal action potential ( J:175137 )

• duration of action potential at half-maximal amplitude is decreased compared to in wild-type cells

abnormal afterhyperpolarization ( J:175137 )

• after-hyperpolarization amplitude is increased compared to in wild-type cells

abnormal neuron physiology ( J:175137 )

• dorsal root ganglia neurons exhibit reduced potassium current amplitude compared to in wild-type cells

• neurons exhibit higher sensitivity to depolarizing stimuli compared with wild-type cells

• neurons at pH6.0 or treated with quinidine exhibit greater inhibition of potassium conductance compared with similarly treated wild-type cells

• however, bupivacaine-mediated inhibition of potassium conductance is normal

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