All Phenotypes Mdm4<tm1Zmy> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mdm4^tm1Zmy
targeted mutation 1, Zhi-Min Yuan
MGI:5141749

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm4^tm1Zmy/Mdm4^tm1Zmy	involves: 129 * C57BL/6	MGI:5141751
cx2	Mdm4^tm1Zmy/Mdm4^tm1Zmy Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6	MGI:5141752

Allelic Composition	Mdm4^tm1Zmy/Mdm4^tm1Zmy
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Zmy mutation (0 available); any Mdm4 mutation (190 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:174359 )

• begin to die around E9.5 and all are dead by E13.5

cellular

increased embryonic tissue cell apoptosis ( J:174359 )

• in embryos at E9.5

decreased cell proliferation ( J:174359 )

• in embryos at E9.5

embryo

increased embryonic tissue cell apoptosis ( J:174359 )

• in embryos at E9.5

decreased embryo size ( J:174359 )

abnormal embryonic neuroepithelium morphology ( J:174359 )

• begin to die around E9.5 and all are dead by E13.5

absent somites ( J:174359 )

• abnormal embryos lack somites at E9.5

growth/size/body

decreased embryo size ( J:174359 )

cardiovascular system

abnormal heart development ( J:174359 )

• abnormal embryos lack hearts at E9.5

nervous system

abnormal embryonic neuroepithelium morphology ( J:174359 )

• begin to die around E9.5 and all are dead by E13.5

Allelic Composition	Mdm4^tm1Zmy/Mdm4^tm1Zmy Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Zmy mutation (0 available); any Mdm4 mutation (190 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:174359 )

• phenotypes are almost identical to control littermates

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