Phenotypes associated with this allele

• Allele Symbol: Cdk6^tm4.1Phin
• Allele Name: targeted mutation 4.1, Philip Hinds
• Allele ID: MGI:5141516
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk6^tm4.1Phin/Cdk6^tm4.1Phin	involves: 129 * C57BL/6 * FVB/N	MGI:5141603

Genotype
MGI:5141603

hm1

• Allelic Composition: Cdk6^tm4.1Phin/Cdk6^tm4.1Phin
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

small thymus ( J:174697 )

• compared to in Cdk6^tm1.1Phin homozygotes

decreased thymocyte number ( J:174697 )

• 6-fold compared to in Cdk6^tm1.1Phin homozygotes

decreased DN1 thymic pro-T cell number ( J:174697 )

• 3 times compared to in Cdk6^tm1.1Phin homozygotes

decreased DN2 thymocyte number ( J:174697 )

• 2 times compared to in Cdk6^tm1.1Phin homozygotes

decreased DN4 thymocyte number ( J:174697 )

• marginal compared to in Cdk6^tm1.1Phin homozygotes

abnormal T cell differentiation ( J:174697 )

• fewer DN3 cells are in the S-G2-M phases of the cell cycle compared to in Cdk6^tm1.1Phin homozygotes

increased DN3 thymocyte number ( J:174697 )

• 1.8-fold compared to in Cdk6^tm1.1Phin homozygotes

decreased double-positive T cell number ( J:174697 )

• compared to in Cdk6^tm1.1Phin homozygotes

increased CD4-positive, alpha-beta T cell number ( J:174697 )

• compared to in Cdk6^tm1.1Phin homozygotes

increased CD8-positive, alpha-beta T cell number ( J:174697 )

• compared to in Cdk6^tm1.1Phin homozygotes

increased hematopoietic stem cell number ( J:174697 )

• the LSK fraction is increased 4-fold compared to in Cdk6^tm1.1Phin homozygotes

• however, the number of hematopoietic stem cell is the same as in Cdk6^tm1.1Phin homozygotes

abnormal hematopoietic stem cell physiology ( J:174697 )

• mice exhibit a 42% increase in the fraction of cycling LSK cells compared with Cdk6^tm1.1Phin homozygotes

immune system

immune system phenotype ( J:174697 )

N • mice exhibit normal numbers of double negative T cells

small thymus ( J:174697 )

• compared to in Cdk6^tm1.1Phin homozygotes

decreased thymocyte number ( J:174697 )

• 6-fold compared to in Cdk6^tm1.1Phin homozygotes

decreased DN1 thymic pro-T cell number ( J:174697 )

• 3 times compared to in Cdk6^tm1.1Phin homozygotes

decreased DN2 thymocyte number ( J:174697 )

• 2 times compared to in Cdk6^tm1.1Phin homozygotes

decreased DN4 thymocyte number ( J:174697 )

• marginal compared to in Cdk6^tm1.1Phin homozygotes

abnormal T cell differentiation ( J:174697 )

• fewer DN3 cells are in the S-G2-M phases of the cell cycle compared to in Cdk6^tm1.1Phin homozygotes

increased DN3 thymocyte number ( J:174697 )

• 1.8-fold compared to in Cdk6^tm1.1Phin homozygotes

decreased double-positive T cell number ( J:174697 )

• compared to in Cdk6^tm1.1Phin homozygotes

increased CD4-positive, alpha-beta T cell number ( J:174697 )

• compared to in Cdk6^tm1.1Phin homozygotes

increased CD8-positive, alpha-beta T cell number ( J:174697 )

• compared to in Cdk6^tm1.1Phin homozygotes

endocrine/exocrine glands

small thymus ( J:174697 )

• compared to in Cdk6^tm1.1Phin homozygotes

decreased thymocyte number ( J:174697 )

• 6-fold compared to in Cdk6^tm1.1Phin homozygotes

decreased DN1 thymic pro-T cell number ( J:174697 )

• 3 times compared to in Cdk6^tm1.1Phin homozygotes

decreased DN2 thymocyte number ( J:174697 )

• 2 times compared to in Cdk6^tm1.1Phin homozygotes

decreased DN4 thymocyte number ( J:174697 )

• marginal compared to in Cdk6^tm1.1Phin homozygotes

increased DN3 thymocyte number ( J:174697 )

• 1.8-fold compared to in Cdk6^tm1.1Phin homozygotes