Phenotypes associated with this allele

• Allele Symbol: Cdk6^tm3.1Phin
• Allele Name: targeted mutation 3.1, Philip Hinds
• Allele ID: MGI:5141515
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk6^tm3.1Phin/Cdk6^tm3.1Phin	involves: 129 * C57BL/6 * FVB/N	MGI:5141602

Genotype
MGI:5141602

hm1

• Allelic Composition: Cdk6^tm3.1Phin/Cdk6^tm3.1Phin
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell apoptosis ( J:174697 )

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

enlarged thymus ( J:174697 )

• compared with

increased thymocyte number ( J:174697 )

• 1.5-fold compared with Cdk6^tm1.1Phin homozygotes

increased DN1 thymic pro-T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

abnormal T cell differentiation ( J:174697 )

• mice exhibit a greater proportion of DN2 and DN3 cells in the S-G2-M phases of the cell cycle compared with Cdk6^tm1.1Phin homozygotes

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

increased CD4-positive, alpha-beta T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

increased hematopoietic stem cell number ( J:174697 )

• in the LSK fraction and absolute number of LSK cells compared with Cdk6^tm1.1Phin homozygotes

abnormal hematopoietic stem cell physiology ( J:174697 )

• mice exhibit a 37% increase in the fraction of cycling LSK cells compared with Cdk6^tm1.1Phin homozygotes

• mice exhibit an increase in LSK cell apoptosis compared with Cdk6^tm1.1Phin homozygotes

immune system

immune system phenotype ( J:174697 )

N • mice exhibit normal numbers of DN2 through DN4 cells

increased T cell apoptosis ( J:174697 )

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

enlarged thymus ( J:174697 )

• compared with

increased thymocyte number ( J:174697 )

• 1.5-fold compared with Cdk6^tm1.1Phin homozygotes

increased DN1 thymic pro-T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

abnormal T cell differentiation ( J:174697 )

• mice exhibit a greater proportion of DN2 and DN3 cells in the S-G2-M phases of the cell cycle compared with Cdk6^tm1.1Phin homozygotes

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

increased CD4-positive, alpha-beta T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

cellular

increased T cell apoptosis ( J:174697 )

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

endocrine/exocrine glands

enlarged thymus ( J:174697 )

• compared with

increased thymocyte number ( J:174697 )

• 1.5-fold compared with Cdk6^tm1.1Phin homozygotes

increased DN1 thymic pro-T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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