Phenotypes associated with this allele

• Allele Symbol: Gngt1^tm1Ogk
• Allele Name: targeted mutation 1, Oleg G Kisselev
• Allele ID: MGI:5140545
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gngt1^tm1Ogk/Gngt1^tm1Ogk	involves: 129	MGI:5140547
ht2	Gngt1^tm1Ogk/Gngt1^+	involves: 129	MGI:5140548

Genotype
MGI:5140547

hm1

• Allelic Composition: Gngt1^tm1Ogk/Gngt1^tm1Ogk
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina outer nuclear layer degeneration ( J:173381 )

retina degeneration ( J:173381 )

• at 3 to 4 months, mice exhibit slow progressive retinal degeneration unlike in wild-type mice

• however, early adult mice do not exhibit degeneration

abnormal eye electrophysiology ( J:173381 )

• mice exhibit increased half-saturating light intensity and decreased time to peak, integration time, time constant of single-exponential decay of dim flash response recovery phase, and dominant time constant of recovery after saturating flashes compared with wild-type mice

abnormal rod electrophysiology ( J:173381 )

• at 2 months, scotopic visual sensitivity is reduced compared to in wild-type mice

• scotopic spatial contrast sensitivity is shifted 100-fold to brighter light conditions compared to in wild-type mice

• a-wave sensitivity is decreased 33-fold and maximal amplitude is decreased 2-fold compared to in wild-type mice

• the amplitude of scotopic b-wave is decreased and b-wave sensitivity is decreased 38-fold compared with wild-type mice

• rod light sensitivity is decreased 90-fold compared to in wild-type rods

• rising phase rod response requires a 40-fold increase in flash strength compared with wild-type rods

• phototransduction amplification is reduced 33-fold compared with to in wild-type mice

• the inactivation rate of dim flash photoresponse is accelerated compared to in wild-type mice

Genotype
MGI:5140548

ht2

• Allelic Composition: Gngt1^tm1Ogk/Gngt1⁺
• Genetic Background: involves: 129

vision/eye

abnormal eye electrophysiology ( J:173381 )

• mice exhibit increased half-saturating light intensity and decreased time to peak and dominant time constant of recovery after saturating flashes compared with wild-type mice

abnormal rod electrophysiology ( J:173381 )

• rod light sensitivity is decreased 1.4-fold compared to in wild-type rods