All Phenotypes Igh<tm1.1Twin> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1.1Twin/Igh^tm1.1Twin	involves: 129 * 129S4/SvJae * C57BL/6	MGI:5140411
ht2	Igh^tm1.1Twin/Igh⁺	involves: 129 * 129S4/SvJae * C57BL/6	MGI:5140413
cx3	Igh^tm1.1Twin/Igh^tm1.1Twin Siglecg^tm1Lnit/Siglecg^tm1Lnit	involves: 129 * 129S4/SvJae * BALB/c * C57BL/6	MGI:5140414
cx4	Igh^tm1.1Twin/Igh^tm1.1Twin Plcg2^Ali5/Plcg2⁺	involves: 129 * 129S4/SvJae * C3HeB/FeJ * C57BL/6	MGI:5140412

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:174233 )

N	• VDJ-recombination is normal

abnormal B cell morphology ( J:174233 )

• BAFF-treated B cells exhibit less of an increase in cell size than wild-type mice

abnormal B cell differentiation ( J:174233 )

• bone marrow B cell development is partially blocked at the pro-B to pre-B, the pre-B to immature B, and the immature B to mature B-cell stages compared to in wild-type mice

abnormal B cell number ( J:174233 )

• mice exhibit an increase in the ratios of pre-B to immature B cells and immature B cells to mature B cells compared to in wild-type mice

• the ratio of follicular to marginal zone B cells is decreased compared to in wild-type mice

decreased B cell number ( J:174233 )

• in bone marrow lymphocyte population

decreased immature B cell number ( J:174233 )

decreased transitional stage T2 B cell number ( J:174233 )

• slightly

decreased mature B cell number ( J:174233 )

decreased B-1a cell number ( J:174233 )

• severely in the peritoneum

decreased follicular B cell number ( J:174233 )

• severe

absent plasma cells ( J:174233 )

• extrafollicular IgM-secreting plasma cells (IgMhigh) are almost completely absent in splenic sections unlike in wild-type mice

abnormal marginal zone B cell morphology ( J:174233 )

• mice exhibit a relative increase in marginal zone (MZ) B cell without an increase in the absolute number of MZ B cells

decreased IgG level ( J:174233 )

• 3-fold in unstimulated mice

decreased IgG3 level ( J:174233 )

• 10-fold in response to trinitrophenol (TNP) stimulation after 8 days

decreased IgM level ( J:174233 )

• 10-fold in unstimulated mice

• 100-fold in response to trinitrophenol (TNP) stimulation after 8 days

• in LPS-stimulated B cells

abnormal marginal zone B cell physiology ( J:174233 )

• upon BCR stimulation, marginal zone B cells exhibit lower sustained calcium release compared with wild-type cells

hematopoietic system

abnormal B cell morphology ( J:174233 )

• BAFF-treated B cells exhibit less of an increase in cell size than wild-type mice

abnormal B cell differentiation ( J:174233 )

• bone marrow B cell development is partially blocked at the pro-B to pre-B, the pre-B to immature B, and the immature B to mature B-cell stages compared to in wild-type mice

abnormal B cell number ( J:174233 )

• mice exhibit an increase in the ratios of pre-B to immature B cells and immature B cells to mature B cells compared to in wild-type mice

• the ratio of follicular to marginal zone B cells is decreased compared to in wild-type mice

decreased B cell number ( J:174233 )

• in bone marrow lymphocyte population

decreased immature B cell number ( J:174233 )

decreased transitional stage T2 B cell number ( J:174233 )

• slightly

decreased mature B cell number ( J:174233 )

decreased B-1a cell number ( J:174233 )

• severely in the peritoneum

decreased follicular B cell number ( J:174233 )

• severe

absent plasma cells ( J:174233 )

• extrafollicular IgM-secreting plasma cells (IgMhigh) are almost completely absent in splenic sections unlike in wild-type mice

abnormal marginal zone B cell morphology ( J:174233 )

• mice exhibit a relative increase in marginal zone (MZ) B cell without an increase in the absolute number of MZ B cells

decreased IgG level ( J:174233 )

• 3-fold in unstimulated mice

decreased IgG3 level ( J:174233 )

• 10-fold in response to trinitrophenol (TNP) stimulation after 8 days

decreased IgM level ( J:174233 )

• 10-fold in unstimulated mice

• 100-fold in response to trinitrophenol (TNP) stimulation after 8 days

• in LPS-stimulated B cells

abnormal marginal zone B cell physiology ( J:174233 )

• upon BCR stimulation, marginal zone B cells exhibit lower sustained calcium release compared with wild-type cells

Allelic Composition	Igh^tm1.1Twin/Igh⁺
Genetic Background	involves: 129 * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.1Twin mutation (0 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased pro-B cell number ( J:174233 )

decreased pre-B cell number ( J:174233 )

• slightly

hematopoietic system

increased pro-B cell number ( J:174233 )

decreased pre-B cell number ( J:174233 )

• slightly

Allelic Composition	Igh^tm1.1Twin/Igh^tm1.1Twin Siglecg^tm1Lnit/Siglecg^tm1Lnit
Genetic Background	involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.1Twin mutation (0 available); any Igh mutation (43 available)
Siglecg^tm1Lnit mutation (0 available); any Siglecg mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:174233 )

N	• mice exhibit normal levels of B1a, B1b, and B2 cells

Allelic Composition	Igh^tm1.1Twin/Igh^tm1.1Twin Plcg2^Ali5/Plcg2⁺
Genetic Background	involves: 129 * 129S4/SvJae * C3HeB/FeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.1Twin mutation (0 available); any Igh mutation (43 available)
Plcg2^Ali5 mutation (0 available); any Plcg2 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:174233 )

N	• the distribution of B cell subsets in the peritoneal cavity is normal

increased B-1a cell number ( J:174233 )

• compared with Igh^tm1.1Twin homozygotes

hematopoietic system

increased B-1a cell number ( J:174233 )

• compared with Igh^tm1.1Twin homozygotes

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