Phenotypes associated with this allele

• Allele Symbol: Ecscr^tm1Iked
• Allele Name: targeted mutation 1, Koji Ikeda
• Allele ID: MGI:5140166
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ecscr^tm1Iked/Ecscr^tm1Iked	Not Specified	MGI:5140174

Genotype
MGI:5140174

hm1

• Allelic Composition: Ecscr^tm1Iked/Ecscr^tm1Iked
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Nonfatal bleeding in Ecscr^tm1Iked/Ecscr^tm1Iked embryos

cardiovascular system

abnormal vascular endothelial cell migration ( J:173348 )

• following critical limb ischemia

hemorrhage ( J:173348 )

• at E14.5, mice exhibit nonfatal bleeding unlike wild-type mice

decreased vascular endothelial cell apoptosis ( J:173348 )

• following critical limb ischemia, endothelial cell apoptosis is decreased compared to in wild-type mice

pathological neovascularization ( J:173348 )

• following critical limb ischemia, mice exhibit increased blood flow and capillary density compared with wild-type mice

• bone marrow cells used to reconstituted wild-type mice confer increased blood flow and capillary density following critical limb ischemia

• however, treatment with PI3K or NOS inhibitors abolishes enhanced ischemia-induced neovascularization

cellular

abnormal vascular endothelial cell migration ( J:173348 )

• following critical limb ischemia

decreased vascular endothelial cell apoptosis ( J:173348 )

• following critical limb ischemia, endothelial cell apoptosis is decreased compared to in wild-type mice