Ecscr^tm1Iked
Targeted Allele Detail

Summary

• Symbol: Ecscr^tm1Iked
• Name: endothelial cell surface expressed chemotaxis and apoptosis regulator; targeted mutation 1, Koji Ikeda
• MGI ID: MGI:5140166
• Synonyms: ARIA^-
• Gene: Ecscr Location: Chr18:35846139-35855409 bp, - strand Genetic Position: Chr18, 19.22 cM
• Alliance: Ecscr^tm1Iked page

Nonfatal bleeding in Ecscr^tm1Iked/Ecscr^tm1Iked embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173348
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 1, 2, and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on lung extracts. (J:173348)

Generation of the Ecscr^tm1Iked allele

Expression

In Mice Carrying this Mutation:

19 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ecscr Mutation: 19 strains or lines available

References

• Original: J:173348 Koide M, et al., Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9472-7
• All: 3 reference(s)