Phenotypes associated with this allele

• Allele Symbol: Pex5l^tm1.1Chet
• Allele Name: targeted mutation 1.1, Dane Chetkovich
• Allele ID: MGI:5139912
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pex5l^tm1.1Chet/Pex5l^tm1.1Chet	involves: BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6NTac	MGI:5139999

Genotype
MGI:5139999

hm1

• Allelic Composition: Pex5l^tm1.1Chet/Pex5l^tm1.1Chet
• Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor learning ( J:173355 )

• mice exhibit impaired motor learning in the accelerating rotarod task compared with wild-type mice

abnormal depression-related behavior ( J:173355 )

• mice exhibit less time immobile in forced swim and tail suspension tests compared with wild-type mice

decreased startle reflex ( J:173355 )

abnormal nest building behavior ( J:173355 )

• impaired

nervous system

abnormal neuron physiology ( J:173355 )

• CA1 pyramidal neuron somata and dendrites exhibit reduced hyperpolarization-activated current (Ih) compared with neurons from wild-type mice and Hcn1^tm2Kndl homozygotes