Phenotypes associated with this allele

• Allele Symbol: Aurkb^tm1.2Mama
• Allele Name: targeted mutation 1.2, Marcos Malumbres
• Allele ID: MGI:5056428
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Aurkb^tm1.2Mama/Aurkb^+	involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL	MGI:5056442
ht2	Aurkb^tm1.2Mama/Aurkb^tm2.2Mama	involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL	MGI:5056443

Genotype
MGI:5056442

ht1

• Allelic Composition: Aurkb^tm1.2Mama/Aurkb⁺
• Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:173575 )

• decreased life span due to an increase in spontaneous pathologies

reproductive system

oligozoospermia ( J:173575 )

♂ • seen in some males by 12 months of age

neoplasm

increased tumor incidence ( J:173575 )

increased skin papilloma incidence ( J:173575 )

increased adenocarcinoma incidence ( J:173575 )

• increase in pituitary adenocarcinomas

increased liver adenocarcinoma incidence ( J:173575 )

integument

increased skin papilloma incidence ( J:173575 )

liver/biliary system

increased liver adenocarcinoma incidence ( J:173575 )

cellular

oligozoospermia ( J:173575 )

♂ • seen in some males by 12 months of age

Genotype
MGI:5056443

ht2

• Allelic Composition: Aurkb^tm1.2Mama/Aurkb^tm2.2Mama
• Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

mortality/aging

embryonic lethality ( J:173575 )

• no embryos are found at midgestation

cellular

polyploidy ( J:173575 )

• polyploid cells are seen in the inner cell mass

abnormal mitosis ( J:173575 )

• numerous inner cell mass cells in prometaphase (PM) or metaphase (M) are detected unlike in controls

• in inner cell mass cells from cultured embryos mitotic figures display misaligned chromosomes in the presence of Mad2l1 and Ccnb1

• at E6.5 - E7.5, an increase in the number of mitotic cells is seen, mostly made up of cells in PM and M with misaligned chromosomes

abnormal mitotic spindle morphology ( J:173575 )

• abnormal spindles with a strong concentration of alpha-tubulin in the poles and lack of bipolar fibers in inner cell mass cells

• multipolar spindles are seen

increased embryonic tissue cell apoptosis ( J:173575 )

• in embryos at E6.5 - E7.5

embryo

increased embryonic tissue cell apoptosis ( J:173575 )

• in embryos at E6.5 - E7.5

decreased embryo size ( J:173575 )

• implanted embryos at E6.5 - E9.5 show reduced size and a progressive decrease in the number of cells

abnormal embryonic tissue morphology ( J:173575 )

• defective structures at E6.5

abnormal inner cell mass morphology ( J:173575 )

• deficient outgrowth

abnormal trophoblast giant cell morphology ( J:173575 )

• trophoblasts have altered nucleus size and morphology

decreased trophoblast giant cell number ( J:173575 )

abnormal ectoplacental cone morphology ( J:173575 )

• hemorrhage in the ectoplacental cone at E6.5

cardiovascular system

hemorrhage ( J:173575 )

• hemorrhage in the ectoplacental cone at E6.5

homeostasis/metabolism

edema ( J:173575 )

• frequent edemas at E6.5

growth/size/body

decreased embryo size ( J:173575 )

• implanted embryos at E6.5 - E9.5 show reduced size and a progressive decrease in the number of cells