Aurkb^tm2.2Mama
Targeted Allele Detail

Summary

• Symbol: Aurkb^tm2.2Mama
• Name: aurora kinase B; targeted mutation 2.2, Marcos Malumbres
• MGI ID: MGI:5056433
• Synonyms: Aurkb(Z)
• Gene: Aurkb Location: Chr11:68936473-68942490 bp, + strand Genetic Position: Chr11, 42.32 cM
• Alliance: Aurkb^tm2.2Mama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 - 4 were flanked with wild-type and mutant loxP sites, an inverted IRES-lacZ cassette was inserted between exons 4 and 5 inside the loxP sites, and an FRT flanked neo cassette was inserted between exons 4 and 5 outside the loxP sites via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination inverted the IRES-lacZ cassette and removed exons 2 -4. (J:173575)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aurkb Mutation: 23 strains or lines available

References

• Original: J:173575 Fernandez-Miranda G, et al., Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development. 2011 Jul;138(13):2661-72
• All: 1 reference(s)