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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kiss1rtm1.1(cre)Uboe
targeted mutation 1.1, Ulrich Boehm
MGI:5052305
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Kiss1rtm1.1(cre)Uboe/Kiss1r+ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL MGI:5052331
cn2
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Kiss1rtm1.1(cre)Uboe/Kiss1r+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL MGI:5052332
cn3
 		Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+
Kiss1rtm1.1(cre)Uboe/Kiss1r+ 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL MGI:5052333


Genotype
MGI:5052331
ht1
Allelic
Composition		 Kiss1rtm1.1(cre)Uboe/Kiss1r+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1rtm1.1(cre)Uboe mutation (0 available); any Kiss1r mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:173936 )
• mice are viable with normal fertility




Genotype
MGI:5052332
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Kiss1rtm1.1(cre)Uboe/Kiss1r+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Kiss1rtm1.1(cre)Uboe mutation (0 available); any Kiss1r mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:173936 )
N
• female mice exhibit normal onset of puberty, ovalutory cyclicity, and fertile
abnormal vagina development ( J:173936 )
• female mice exhibit slightly prolonged phases of cornification compared with wild-type mice

nervous system
decreased neuron number ( J:173936 )
• the number of gonadotrophin-releasing hormone neurons in the hypothalamus of female mice is decreased compared to in wild-type mice

endocrine/exocrine glands




Genotype
MGI:5052333
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+
Kiss1rtm1.1(cre)Uboe/Kiss1r+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(HBEGF)Awai mutation (4 available); any Gt(ROSA)26Sor mutation (944 available)
Kiss1rtm1.1(cre)Uboe mutation (0 available); any Kiss1r mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:173936 )
N
• diphtheria-treated mice exhibit normal ovalutory cyclicity and fertility

nervous system
decreased neuron number ( J:173936 )
• diphtheria-treated mice exhibit ablation of Kiss1r+ and gonadotrophin-releasing hormone neurons




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory