Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm1.1(cre)Bz mutation
(0 available);
any
Nfatc1 mutation
(47 available)
Pdcd10tm1Kwhi mutation
(0 available);
any
Pdcd10 mutation
(18 available)
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mortality/aging
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• embryonic lethality, with all fetuses dead by E15.5-E17.5
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cardiovascular system
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• embryos exhibit a reduction in myocardial growth at E12.5
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• embryos exhibit reduced cardiac jelly at E12.5 as indicated by reduced matrix glycosaminoglycans and versican in the heart
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muscle
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• embryos exhibit a reduction in myocardial growth at E12.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1.1Kwhi mutation
(0 available);
any
Pdcd10 mutation
(18 available)
Pdcd10tm1Kwhi mutation
(0 available);
any
Pdcd10 mutation
(18 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation
(0 available)
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mortality/aging
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• increased early mortality
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cardiovascular system
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• cerebral cavernous malformations develop by one month after tamoxifen treatment at 1 day of age
• additional abnormalities include capillary telangiectasias, isolated caverns and multiple back to back caverns, thrombosis, hemorrhage, formation of secondary channels
• attenuation of endothelial cells in larger secondary channels but no gaps
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• foot processes are missing
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nervous system
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• cerebral cavernous malformations develop by one month after tamoxifen treatment at 1 day of age
• additional abnormalities include capillary telangiectasias, isolated caverns and multiple back to back caverns, thrombosis, hemorrhage, formation of secondary channels
• attenuation of endothelial cells in larger secondary channels but no gaps
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• foci of mononuclear inflammatory cells also seen
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• foot processes are missing
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immune system
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• foci of mononuclear inflammatory cells also seen
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1Kwhi mutation
(0 available);
any
Pdcd10 mutation
(18 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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mortality/aging
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• death due to venous rupture by E13.5
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cardiovascular system
N |
• open branchial arch arteries and developed circulatory system at E9.5
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• progressive enlargement of the cardinal vein until E11.5
• death due to venous rupture by E13.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1Kwhi mutation
(0 available);
any
Pdcd10 mutation
(18 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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normal phenotype
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• born alive with no obvious defects when the conditional deletion occurs in neural and glial tissue
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