Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-PIK3CA*H1047R,-EGFP)Balj}
• Allele Name: targeted mutation 1, Mohamed Bentires-Alj
• Allele ID: MGI:5052133
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor^+ Tg(Wap-cre)1Gsc/0	involves: BALB/c * C57BL/6 * FVB/N	MGI:5052138
cn2	Gt(ROSA)26Sor^tm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor^+ Tg(MMTV-cre)7Mul/0	involves: BALB/c * FVB/N	MGI:5052139

Genotype
MGI:5052138

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-PIK3CA*H1047R,-EGFP)Balj}/Gt(ROSA)26Sor⁺; Tg(Wap-cre)1Gsc/0
• Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:173655 )

• parous mice develop mammary tumors 37 days after delivery of pups (at 140 days) unlike Tg(Wap-cre)1Gsc mice

• mammary tumors are heterogeneous (adenosquamous carcinoma, adenomyoepitheliomas, adenocarcinomas with squamouse metaplasia, adenocarcinomas, and adenocarcinomatosis)

increased mammary adenocarcinoma incidence ( J:173655 )

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:173655 )

♀ • delayed due to reduced cell death

increased mammary gland tumor incidence ( J:173655 )

• parous mice develop mammary tumors 37 days after delivery of pups (at 140 days) unlike Tg(Wap-cre)1Gsc mice

• mammary tumors are heterogeneous (adenosquamous carcinoma, adenomyoepitheliomas, adenocarcinomas with squamouse metaplasia, adenocarcinomas, and adenocarcinomatosis)

increased mammary adenocarcinoma incidence ( J:173655 )

integument

abnormal involution of the mammary gland ( J:173655 )

♀ • delayed due to reduced cell death

increased mammary gland tumor incidence ( J:173655 )

• parous mice develop mammary tumors 37 days after delivery of pups (at 140 days) unlike Tg(Wap-cre)1Gsc mice

• mammary tumors are heterogeneous (adenosquamous carcinoma, adenomyoepitheliomas, adenocarcinomas with squamouse metaplasia, adenocarcinomas, and adenocarcinomatosis)

increased mammary adenocarcinoma incidence ( J:173655 )

Genotype
MGI:5052139

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-PIK3CA*H1047R,-EGFP)Balj}/Gt(ROSA)26Sor⁺; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: BALB/c * FVB/N

mortality/aging

premature death ( J:173655 )

• 75% of mice die before 4 months of age

neoplasm

increased mammary adenocarcinoma incidence ( J:173655 )

• in 25% of mice after 214 days unlike Tg(MMTV-cre)7Mul mice

• mammary tumors are heterogeneous (adenomyoepitheliomas)

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:173655 )

• in 25% of mice after 214 days unlike Tg(MMTV-cre)7Mul mice

• mammary tumors are heterogeneous (adenomyoepitheliomas)

integument

increased mammary adenocarcinoma incidence ( J:173655 )

• in 25% of mice after 214 days unlike Tg(MMTV-cre)7Mul mice

• mammary tumors are heterogeneous (adenomyoepitheliomas)