Phenotypes associated with this allele

• Allele Symbol: Mcoln1^tm1Asoy
• Allele Name: targeted mutation 1, Abigail Soyombo-Shoola
• Allele ID: MGI:5050099
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcoln1^tm1Asoy/Mcoln1^tm1Asoy	involves: 129 * C57BL/6	MGI:5050100

Genotype
MGI:5050100

hm1

• Allelic Composition: Mcoln1^tm1Asoy/Mcoln1^tm1Asoy
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:173516 )

• growth and survival are normal to 6 months of age

• growth retardation after 6 months

behavior/neurological

hindlimb paralysis ( J:173516 )

• after 6 months

digestive/alimentary system

abnormal stomach morphology ( J:173516 )

abnormal gastric parietal cell morphology ( J:173516 )

• parietal cells at 4 weeks of age are grossly enlarged

• numerous vacuoles are present at 4 weeks

• lysosomes are enlarged

• poorly developed intracellular canaliculi network after histamine stimulation

enlarged stomach ( J:173516 )

• increased stomach mass

increased stomach pH ( J:173516 )

• basal stomach acid content at 16 weeks of age is significantly reduced

homeostasis/metabolism

increased circulating gastrin level ( J:173516 )

• elevated serum gastrin levels

endocrine/exocrine glands

abnormal gastric parietal cell morphology ( J:173516 )

• parietal cells at 4 weeks of age are grossly enlarged

• numerous vacuoles are present at 4 weeks

• lysosomes are enlarged

• poorly developed intracellular canaliculi network after histamine stimulation