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Targeted Allele Detail
Symbol: Mcoln1tm1Asoy
Name: mucolipin 1; targeted mutation 1, Abigail Soyombo-Shoola
MGI ID: MGI:5050099
Synonyms: Trpml1-
Gene: Mcoln1  Location: Chr8:3550458-3565232 bp, + strand  Genetic Position: Chr8, 1.92 cM
Alliance: Mcoln1tm1Asoy page
Germline Transmission:  Earliest citation of germline transmission: J:173516
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA tetracycline responsive transcriptional activator was place downstream of the promoter followed by a neomycin selection cassette. This insertion replaced exons 1 and 2 and part of exon 3. Northern blot analysis of brain RNA confirmed the absence of mRNA. (J:173516)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mcoln1 Mutation:  27 strains or lines available
Original:  J:173516 Chandra M, et al., A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice. Gastroenterology. 2011 Mar;140(3):857-67
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory