Phenotypes associated with this allele

• Allele Symbol: Zfp871^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:5014690
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp871^tm1a(EUCOMM)Wtsi/Zfp871^tm1a(EUCOMM)Wtsi	C57BL/6N-Zfp871^tm1a(EUCOMM)Wtsi/BayMmucd	MGI:7517188
ht2	Zfp871^tm1a(EUCOMM)Wtsi/Zfp871^+	C57BL/6N-Zfp871^tm1a(EUCOMM)Wtsi/BayMmucd	MGI:7517194
cx3	Trp53^tm1Tyj/Trp53^+ Zfp871^tm1a(EUCOMM)Wtsi/Zfp871^tm1a(EUCOMM)Wtsi	involves: 129S2/SvPas * C57BL/6N	MGI:7517192

Genotype
MGI:7517188

hm1

• Allelic Composition: Zfp871^{tm1a(EUCOMM)Wtsi}/Zfp871^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Zfp871^{tm1a(EUCOMM)Wtsi}/BayMmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased birth body size ( J:317166 )

• the single viable pup was less than half the size of littermates

mortality/aging

postnatal lethality, complete penetrance ( J:317166 )

• the single viable pup survived for 17 days

prenatal lethality, incomplete penetrance ( J:317166 )

• out of 52 pups from 10 litters only a single homozygous pup was born alive

Genotype
MGI:7517194

ht2

• Allelic Composition: Zfp871^{tm1a(EUCOMM)Wtsi}/Zfp871⁺
• Genetic Background: C57BL/6N-Zfp871^{tm1a(EUCOMM)Wtsi}/BayMmucd

neoplasm

neoplasm ( J:317166 )

N • not prone to spontaneous tumors but do show a shift in tumor spectrum

decreased lymphoma incidence ( J:317166 )

• no incidence of T-cell lymphoma compared to 3.7% in wild-type mice

increased B cell derived lymphoma incidence ( J:317166 )

• slightly increased,16.7% incidence compared to 11.8% in wild-type mice

liver/biliary system

liver inflammation ( J:317166 )

• steatohepatitis in 50% of mice compared to 6% in wild-type mice

hepatic steatosis ( J:317166 )

• steatohepatitis in 50% of mice compared to 6% in wild-type mice

endocrine/exocrine glands

thymus hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

hematopoietic system

thymus hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

spleen hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

growth/size/body

decreased body size ( J:317166 )

spleen hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

immune system

thymus hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

spleen hyperplasia ( J:317166 )

• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice

liver inflammation ( J:317166 )

• steatohepatitis in 50% of mice compared to 6% in wild-type mice

mortality/aging

premature death ( J:317166 )

• median survival time (89.3 weeks) is decreased compared to wild-type controls (117 weeks)

Genotype
MGI:7517192

cx3

• Allelic Composition: Trp53^tm1Tyj/Trp53⁺; Zfp871^{tm1a(EUCOMM)Wtsi}/Zfp871^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: 129S2/SvPas * C57BL/6N

growth/size/body

decreased birth body size ( J:317166 )

• pups are about half the size of heterozygous littermates

mortality/aging

postnatal lethality, complete penetrance ( J:317166 )

• 3 pups were born alive, out of 33 pups in seven litters, but two died 1 day after birth and the third died at P24