All Phenotypes Lrp5<tm3.2Mawa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lrp5^tm3.2Mawa
targeted mutation 3.2, Matthew Warman
MGI:5014217

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa	involves: 129S1/Sv	MGI:5550511
hm2	Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa	involves: 129S1/Sv * C57BL/6J * FVB/N * SJL	MGI:5014232
cx3	Hivep3^tm1Glm/Hivep3^tm1Glm Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa	involves: 129S1/Sv * C57BL/6	MGI:5550512

Allelic Composition	Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm3.2Mawa mutation (0 available); any Lrp5 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Analysis of bone mass in Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa, Hivep3^tm1Glm/Hivep3^tm1Glm, and double mutant mice

skeleton

abnormal bone trabecula morphology ( J:201597 )

• increased trabecula spacing

decreased bone mass ( J:201597 )

• in cortical and trabecular bone

Allelic Composition	Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa
Genetic Background	involves: 129S1/Sv * C57BL/6J * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm3.2Mawa mutation (0 available); any Lrp5 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased bone mass ( J:172746 )

Allelic Composition	Hivep3^tm1Glm/Hivep3^tm1Glm Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (106 available)
Lrp5^tm3.2Mawa mutation (0 available); any Lrp5 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Analysis of bone mass in Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa, Hivep3^tm1Glm/Hivep3^tm1Glm, and double mutant mice

skeleton

increased bone volume ( J:201597 )

• partially rescued from Hivep3^tm1Glm homozygotes

increased compact bone thickness ( J:201597 )

• partially rescued from Hivep3^tm1Glm homozygotes

abnormal bone trabecula morphology ( J:201597 )

• decreased trabecula spacing partially rescued from Hivep3^tm1Glm homozygotes

increased bone trabecula number ( J:201597 )

• partially rescued from Hivep3^tm1Glm homozygotes

increased trabecular bone thickness ( J:201597 )

• partially rescued from Hivep3^tm1Glm homozygotes

increased bone mass ( J:201597 )

• osteosclerotic bone phenotype is partially rescued as in Hivep3^tm1Glm homozygotes

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