All Phenotypes Hormad1<tm1.2Atot> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hormad1^tm1.2Atot/Hormad1^tm1.2Atot	involves: 129/Sv * BALB/c * C57BL/6 * SJL	MGI:5013562
cx2	Hormad1^tm1.2Atot/Hormad1^tm1.2Atot Spo11^tm1Mjn/Spo11^tm1Mjn	involves: 129/Sv * BALB/c * C57BL/6 * SJL	MGI:5013563
cx3	Dmc1^tm1Jcs/Dmc1^tm1Jcs Hormad1^tm1.2Atot/Hormad1^tm1.2Atot	involves: 129/Sv * BALB/c * C57BL/6 * SJL	MGI:5013564

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:173089 )

N	• oocyte numbers are normal

azoospermia ( J:173089 )

• male mice lack post-meiotic cells

abnormal male germ cell apoptosis ( J:173089 )

• spermatocytes are eliminated at a stage equivalent to mid-pachytene unlike in wild-type mice

• spermatocytes are eliminated in stage-IV tubules unlike in wild-type mice

abnormal chiasmata formation ( J:173089 )

• oocytes contain fewer chiasmata than wild-type cells

abnormal female meiosis ( J:173089 )

• in female germ cells, autosomal synaptonemal-complex formation is never completed unlike in wild-type cells

• pseudo-sex-body-like formation is impaired compared to in wild-type cells

• polar-body extrusion is impaired compared to in wild-type cells

• chromosomes fail to align along abnormally long meiosis I spindle unlike in wild-type cells

• oocytes contain fewer chiasmata than in wild-type cells

• however, oocytes exhibit normal nuclear envelop breakdown

abnormal male meiosis ( J:173089 )

• in male germ cells, autosomal synaptonemal-complex formation is never completed unlike in wild-type cells

• sex-body formation is impaired compared to in wild-type cells

abnormal synaptonemal complex ( J:173089 )

• autosomal synaptonemal-complex formation in spermatocytes and oocytes is never completed unlike in wild-type cells

arrest of spermatogenesis ( J:173089 )

• spermatocytes are eliminated at a stage equivalent to mid-pachytene unlike in wild-type mice

• spermatocytes are eliminated in stage-IV tubules unlike in wild-type mice

female infertility ( J:173089 )

male infertility ( J:173089 )

cellular

azoospermia ( J:173089 )

• male mice lack post-meiotic cells

abnormal male germ cell apoptosis ( J:173089 )

• spermatocytes are eliminated at a stage equivalent to mid-pachytene unlike in wild-type mice

• spermatocytes are eliminated in stage-IV tubules unlike in wild-type mice

abnormal double-strand DNA break repair ( J:173089 )

• spermatocytes and oocytes exhibit reduced steady-state numbers of single-stranded double-strand break repair (DSB) ends compared to wild-type cells

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:173089 )

• spermatocytes and oocytes exhibit reduced steady-state numbers of single-stranded double-strand break repair (DSB) ends compared to wild-type cells

Allelic Composition	Hormad1^tm1.2Atot/Hormad1^tm1.2Atot Spo11^tm1Mjn/Spo11^tm1Mjn
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad1^tm1.2Atot mutation (0 available); any Hormad1 mutation (31 available)
Spo11^tm1Mjn mutation (2 available); any Spo11 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:173089 )

N	• unlike in Spo11^tm1Sky homozygotes, oocyte numbers are normal

abnormal female meiosis ( J:173089 )

• pseudo-sex-body-like formation is impaired compared to in wild-type cells

abnormal male meiosis ( J:173089 , J:292036 )

• sex-body formation is impaired compared to in wild-type cells (J:173089)

• absence of double-stranded breaks (DSBs) in spermatocytes (J:292036)

• absence of BRME1 and RPA2 punctuate foci in spermatocytes (J:292036)

abnormal synaptonemal complex ( J:173089 )

• synaptonemal-complex defects are more severe than either single homozygote

Allelic Composition	Dmc1^tm1Jcs/Dmc1^tm1Jcs Hormad1^tm1.2Atot/Hormad1^tm1.2Atot
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1^tm1Jcs mutation (1 available); any Dmc1 mutation (16 available)
Hormad1^tm1.2Atot mutation (0 available); any Hormad1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal double-strand DNA break repair ( J:173089 )

• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:173089 )

• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells

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