All Phenotypes Gt(ROSA)26Sor<tm2Thl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^tm2Thl
targeted mutation 2, Thomas Ludwig
MGI:5008628

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Tyr^c-Brd/Tyr^c-Brd	involves: 129/Sv * 129S4/SvJae * C57BL/6	MGI:5008633
cn2	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Trp53^tm1Thl/Trp53^tm1Thl Tyr^c-Brd/Tyr^c-Brd	involves: 129/Sv * 129S4/SvJae * C57BL/6	MGI:5008634
cn3	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Tyr^c-Brd/Tyr^c-Brd	involves: 129/Sv * C57BL/6	MGI:5008632

Allelic Composition	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Tyr^c-Brd/Tyr^c-Brd
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (81 available)
Tyr^c-Brd mutation (6 available); any Tyr mutation (375 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:172585 )

• median survival is 85 days following injection of PDGF and cre compared with 27 days for similarly treated Pten^tm1Hwu Trp53^tm1Thl double homozygotes

neoplasm

increased glioblastoma incidence ( J:172585 )

• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

nervous system

increased glioblastoma incidence ( J:172585 )

• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
glioblastoma proneural subtype		DOID:0050804		J:172585

Allelic Composition	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Trp53^tm1Thl/Trp53^tm1Thl Tyr^c-Brd/Tyr^c-Brd
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (81 available)
Trp53^tm1Thl mutation (0 available); any Trp53 mutation (232 available)
Tyr^c-Brd mutation (6 available); any Tyr mutation (375 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:172585 )

• median survival is 27 days following injection of PDGF and cre compared with 85 days for similarly treated Pten^tm1Hwu homozygotes

neoplasm

increased tumor growth/size ( J:172585 )

• following injection of PDGF and cre, tumor growth is increased compared to in similarly treated Pten^tm1Hwu homozygotes

increased glioblastoma incidence ( J:172585 )

• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

nervous system

increased glioblastoma incidence ( J:172585 )

• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
glioblastoma proneural subtype		DOID:0050804		J:172585

Allelic Composition	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Tyr^c-Brd/Tyr^c-Brd
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tyr^c-Brd mutation (6 available); any Tyr mutation (375 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:172585 )

N	• following injection of PDGF and cre, mice do not develop tumor-related morbidity

neoplasm

neoplasm ( J:172585 )

N	• following injection of PDGF and cre, mice do not develop tumor-related morbidity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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