Analysis Tools
normal phenotype
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• mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities
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Allele Symbol Allele Name Allele ID |
Pi4katm2.1Arte targeted mutation 2.1, TaconicArtemis MGI:5008158 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• within 10 to 11 days of tamoxifen-induction
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• following tamoxifen-induction, mice exhibit widespread mucosal epithelial degeneration more so in the small and large intestines and less in the stomach compared with control mice
• however, mice do not exhibit a distended intestine morphology
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• focal atypical hyperplasia of mucosal crypts with small clusters of enlarged atypical crypts lined by tall dysplastic basophilic epithelial cells in the small intestine following tamoxifen-induction
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• following tamoxifen-induction, mice exhibit swollen and basophilic surface epithelial cells in the large intestine compared with control mice
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• loss of mucosal crypts in some areas of the large intestine following tamoxifen-induction
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• following tamoxifen-induction, mice exhibit swollen villous epithelial cells with excessive vacuoles in the small intestine compared with control mice
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• following tamoxifen-induction, mice exhibit loose or discolored intestine content
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• thin following tamoxifen-treatment
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• in moribund mice following tamoxifen-induction
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• following tamoxifen-treatment
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• poor coat condition following tamoxifen-treatment
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• loss of mucosal crypts in some areas of the large intestine following tamoxifen-induction
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• focal atypical hyperplasia of mucosal crypts with small clusters of enlarged atypical crypts lined by tall dysplastic basophilic epithelial cells in the small intestine following tamoxifen-induction
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 12 days following tamoxifen-treatment in male mice
• however, female mice remain normal
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• following tamoxifen-treatment, male mice exhibit similar observations as in homozygous conditional knock-ins but with lower severity
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• following tamoxifen-treatment in male mice
• however, female mice remain normal
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• following tamoxifen-treatment in male mice
• however, female mice remain normal
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• following tamoxifen-treatment, one female mouse exhibited a black focal mild discoloration of the spleen
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• poor coat condition following tamoxifen-treatment in male mice
• however, female mice remain normal
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• following tamoxifen-treatment, one female mouse exhibited a black focal mild discoloration of the spleen
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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