mortality/aging
• pups are born at only 40% of the expected number
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respiratory system
• lung tissues show autophagosomal forming structures
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• lungs show several smaller sized secreted lamellar bodies suggesting a phenotype of discharged lamellar bodies
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• autophagy-induced fibrosis
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• decrease in levels of surfactant lipids
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liver/biliary system
• liver tissues show autophagosomal forming structures that partially wrap the mitochondria with the double-membraned phagophore
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• increased densities of hepatic cells
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• autophagy-induced fibrosis
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growth/size/body
• in males but not females
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• in males and females
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hematopoietic system
immune system