Phenotypes associated with this allele

• Allele Symbol: Golga2^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5008102
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Golga2^tm1(KOMP)Vlcg/Golga2^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6362718

Genotype
MGI:6362718

hm1

• Allelic Composition: Golga2^{tm1(KOMP)Vlcg}/Golga2^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:270564 )

• pups are born at only 40% of the expected number

respiratory system

abnormal lung morphology ( J:270564 )

• lung tissues show autophagosomal forming structures

increased alveolar macrophage number ( J:270564 )

abnormal type II pneumocyte morphology ( J:270564 )

• lungs show several smaller sized secreted lamellar bodies suggesting a phenotype of discharged lamellar bodies

pulmonary fibrosis ( J:270564 )

• autophagy-induced fibrosis

abnormal surfactant physiology ( J:270564 )

• decrease in levels of surfactant lipids

liver/biliary system

abnormal liver morphology ( J:270564 )

• liver tissues show autophagosomal forming structures that partially wrap the mitochondria with the double-membraned phagophore

abnormal hepatocyte morphology ( J:270564 )

• increased densities of hepatic cells

liver fibrosis ( J:270564 )

• autophagy-induced fibrosis

growth/size/body

decreased body weight ( J:270564 )

♂ • in males but not females

decreased body length ( J:270564 )

• in males and females

hematopoietic system

increased alveolar macrophage number ( J:270564 )

immune system

increased alveolar macrophage number ( J:270564 )