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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacfd1tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007000
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cacfd1tm1Lex/Cacfd1tm1Lex B6;129S5-Cacfd1tm1Lex/Mmucd MGI:5827855


Genotype
MGI:5827855
hm1
Allelic
Composition		 Cacfd1tm1Lex/Cacfd1tm1Lex
Genetic
Background		 B6;129S5-Cacfd1tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacfd1tm1Lex mutation (1 available); any Cacfd1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased startle reflex ( J:171883 )
• homozygous mutant mice failed to startle during prepulse inhibition testing, suggestive of a possible hearing impairment

homeostasis/metabolism
increased circulating triglyceride level ( J:171883 )
• male and female homozygous mutant mice exhibited increased serum triglyceride levels, the difference being more notable in the females




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory