All Phenotypes Vsir<tm1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vsir^tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5006997

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vsir^tm1Lex/Vsir^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5770297
cx2	Pdcd1^tm1Hon/Pdcd1^tm1Hon Vsir^tm1Lex/Vsir^tm1Lex	involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6	MGI:5770302
cx3	Pdcd1^tm1Hon/Pdcd1^tm1Hon Vsir^tm1Lex/Vsir^tm1Lex Tg(Tcra2D2,Tcrb2D2)1Kuch/0	involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6	MGI:5770303
cx4	Vsir^tm1Lex/Vsir^tm1Lex Tg(Tcra2D2,Tcrb2D2)1Kuch/0	involves: 129S5/SvEvBrd * C57BL/6	MGI:5770298
cx5	Cd274^tm1Igu/Cd274^tm1Igu Vsir^tm1Lex/Vsir^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5770301

Allelic Composition	Vsir^tm1Lex/Vsir^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsir^tm1Lex mutation (2 available); any Vsir mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased IgA level ( J:222944 )

• moderate in aged mice

increased IgM level ( J:222944 )

• moderate in aged mice

abnormal T cell activation ( J:222944 )

• increased CD44^hiCD62L^lo CD8+ and CD4+ T cells at 6 to 7 months of age

• spontaneous activation of peripheral CD4+ and CD8+ T cells

increased interferon-gamma secretion ( J:222944 )

• on in vitro restimulation of T cells

increased interleukin-17 secretion ( J:222944 )

• on in vitro restimulation of T cells

increased inflammatory response ( J:222944 )

• increased leukocyte infiltration with tissue necrosis in several organs including lung, liver and pancreas

endocrine/exocrine glands

pancreas necrosis ( J:222944 )

liver/biliary system

hepatic necrosis ( J:222944 )

respiratory system

pulmonary necrosis ( J:222944 )

hematopoietic system

increased IgA level ( J:222944 )

• moderate in aged mice

increased IgM level ( J:222944 )

• moderate in aged mice

abnormal T cell activation ( J:222944 )

• increased CD44^hiCD62L^lo CD8+ and CD4+ T cells at 6 to 7 months of age

• spontaneous activation of peripheral CD4+ and CD8+ T cells

cellular

hepatic necrosis ( J:222944 )

pancreas necrosis ( J:222944 )

pulmonary necrosis ( J:222944 )

Allelic Composition	Pdcd1^tm1Hon/Pdcd1^tm1Hon Vsir^tm1Lex/Vsir^tm1Lex
Genetic Background	involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1^tm1Hon mutation (6 available); any Pdcd1 mutation (97 available)
Vsir^tm1Lex mutation (2 available); any Vsir mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:222944 )

N	• mice do not develop overt autoimmune disease

increased IgA level ( J:222944 )

• moderate in aged mice

increased IgM level ( J:222944 )

• moderate in aged mice

abnormal T cell activation ( J:222944 )

• increased CD44^hiCD62L^lo CD8+ and CD4+ T cells at 6 to 7 months of age

• spontaneous activation of peripheral CD4+ and CD8+ T cells

increased interferon-gamma secretion ( J:222944 )

• on in vitro restimulation of T cells

• when T cells are challenged with antigen

increased interleukin-17 secretion ( J:222944 )

• on in vitro restimulation of T cells

increased tumor necrosis factor secretion ( J:222944 )

• on in vitro restimulation of T cells

increased inflammatory response ( J:222944 )

• increased leukocyte infiltration with tissue necrosis in several organs including lung, liver and pancreas

endocrine/exocrine glands

pancreas necrosis ( J:222944 )

liver/biliary system

hepatic necrosis ( J:222944 )

respiratory system

pulmonary necrosis ( J:222944 )

hematopoietic system

increased IgA level ( J:222944 )

• moderate in aged mice

increased IgM level ( J:222944 )

• moderate in aged mice

abnormal T cell activation ( J:222944 )

• increased CD44^hiCD62L^lo CD8+ and CD4+ T cells at 6 to 7 months of age

• spontaneous activation of peripheral CD4+ and CD8+ T cells

cellular

hepatic necrosis ( J:222944 )

pancreas necrosis ( J:222944 )

pulmonary necrosis ( J:222944 )

Allelic Composition	Pdcd1^tm1Hon/Pdcd1^tm1Hon Vsir^tm1Lex/Vsir^tm1Lex Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background	involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1^tm1Hon mutation (6 available); any Pdcd1 mutation (97 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
Vsir^tm1Lex mutation (2 available); any Vsir mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:222944 )

• mice exhibit accelerated onset and succumb to complete hindlimb paralysis faster than control mice

Allelic Composition	Vsir^tm1Lex/Vsir^tm1Lex Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
Vsir^tm1Lex mutation (2 available); any Vsir mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:222944 )

• mice exhibit accelerated onset compared with control mice

Allelic Composition	Cd274^tm1Igu/Cd274^tm1Igu Vsir^tm1Lex/Vsir^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274^tm1Igu mutation (0 available); any Cd274 mutation (71 available)
Vsir^tm1Lex mutation (2 available); any Vsir mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell activation ( J:222944 )

• spontaneous activation of peripheral CD4+ and CD8+ T cells

immune system

abnormal T cell activation ( J:222944 )

• spontaneous activation of peripheral CD4+ and CD8+ T cells

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