Phenotypes associated with this allele

• Allele Symbol: Axin2^canp
• Allele Name: canopus
• Allele ID: MGI:5006982
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Axin2^canp/Axin2^canp	C3.B6-Axin2^canp	MGI:5006983
ht2	Axin2^canp/Axin2^tm1Wbm	involves: 129P2/OlaHsd * C3H * C57BL/6J	MGI:5006984

Genotype
MGI:5006983

hm1

• Allelic Composition: Axin2^canp/Axin2^canp
• Genetic Background: C3.B6-Axin2^canp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Embryonic morphogenesis is disrupted in Axin2^canp/Axin2^canp embryos

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:171894 )

• most embryos arrest at mid gestation (E9.5)

embryo

embryonic growth arrest ( J:171894 )

• most embryos (75-80%) arrest at mid gestation (E9.5)

abnormal neural plate morphology ( J:171894 )

• some embryos (20 - 25%) have a double tail phenotype in which the entire spinal neural tube fails to close and a short tail-like structure protrudes from the dorsal side of the neural plate

open neural tube ( J:171894 )

• some embryos (20 - 25%) have a double tail phenotype in which the entire spinal neural tube fails to close and a short tail-like structure protrudes from the dorsal side of the neural plate

abnormal primitive streak morphology ( J:171894 )

• in about 25% of embryos at E7.5

• ectopic protrusions seen in double tail embryos are an expanded population of tail progenitors in the primitive streak

cardiovascular system

abnormal heart morphology ( J:171894 )

• at E9.5

cardia bifida ( J:171894 )

• all embryos show some degree of cardia bifida

nervous system

abnormal neural plate morphology ( J:171894 )

• some embryos (20 - 25%) have a double tail phenotype in which the entire spinal neural tube fails to close and a short tail-like structure protrudes from the dorsal side of the neural plate

open neural tube ( J:171894 )

• some embryos (20 - 25%) have a double tail phenotype in which the entire spinal neural tube fails to close and a short tail-like structure protrudes from the dorsal side of the neural plate

exencephaly ( J:171894 )

• seen in about 30% of embryos

limbs/digits/tail

abnormal tail morphology ( J:171894 )

• about 15% develop ectopic tail like structures

• most embryos (75-80%) have a slightly shortened tail at E9.5

abnormal tail development ( J:171894 )

• ectopic protrusions seen in double tail embryos are an expanded population of tail progenitors in the primitive streak

• the ectopic tail like structures are a protrusion composed of mesenchymal cells that protrude dorsally from the midline of the neural plate

Genotype
MGI:5006984

ht2

• Allelic Composition: Axin2^canp/Axin2^tm1Wbm
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:171894 )

• viable, fertile and do no exhibit the abnormal skull phenotype seen in homozygous null mice