Axin2canp
Chemically induced Allele Detail
|
Symbol: |
Axin2canp |
Name: |
axin 2; canopus |
MGI ID: |
MGI:5006982 |
Synonyms: |
canp |
Gene: |
Axin2 Location: Chr11:108811175-108841609 bp, + strand Genetic Position: Chr11, 71.83 cM
|
Alliance: |
Axin2canp page
|
|
Embryonic morphogenesis is disrupted in Axin2canp/Axin2canp embryos
Show the 5 phenotype image(s) involving this allele.
|
|
|
|
Allele Type: |
|
Chemically induced (ENU) |
Mutation: |
|
Single point mutation
|
|
|
Mutation details: ENU treatment induced a T-to-A mutation, resulting in a valine to aspartic acid substitution at amino acid 26 (p.V26D) in an invariant N-terminal sequence motif. Western blot analysis indicated protein expression was increased 1.6 and 2.2 fold in heterozygous and homozygous embryos, respectively, relative to wild-type mice. Protein half-life is increased in homozygous MEFs relative to wild-type MEFs.
(J:98216, J:171894)
|
Inheritance: |
|
Recessive |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Axin2 Mutation: |
43 strains or lines available
|
|
Original: |
J:171894 Qian L, et al., Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8692-7 |
All: |
2 reference(s) |
|