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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm4Glo
targeted mutation 4, Guillermina Lozano
MGI:5000493
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm4Glo/Trp53tm4Glo involves: 129S7/SvEvBrd * C57BL/6 MGI:5000507
ht2
 		Trp53tm1Glo/Trp53tm4Glo involves: 129S7/SvEvBrd * C57BL/6 MGI:5000505
ht3
 		Trp53tm3.1Glo/Trp53tm4Glo involves: 129S7/SvEvBrd * C57BL/6 MGI:5000508
cn4
 		Trp53tm1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:5000506
cn5
 		Trp53tm3.1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:5000509
cx6
 		Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm4Glo/Trp53tm4Glo 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5142304
cx7
 		Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Glo/Trp53tm4Glo 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5000502
cx8
 		Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm3.1Glo/Trp53tm4Glo 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5000504


Genotype
MGI:5000507
hm1
Allelic
Composition		 Trp53tm4Glo/Trp53tm4Glo
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm4Glo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:171821 )
• medial survival is 395 days due to tumor development

neoplasm
increased lymphoma incidence ( J:171821 )
• in 32% of mice (including T cell and diffuse)
increased sarcoma incidence ( J:171821 )
• in 61% of mice (including angiosarcoma and spindle-cell)

endocrine/exocrine glands




Genotype
MGI:5000505
ht2
Allelic
Composition		 Trp53tm1Glo/Trp53tm4Glo
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Glo mutation (0 available); any Trp53 mutation (232 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:171821 )
• medial survival is 251 days due to tumor development

neoplasm
abnormal tumor morphology ( J:171821 )
• tumors exhibit interstitial inflammatory cells unlike in tumors from Trp53tm1Glo/Trp53tm4Glo Tg(CAG-cre/Esr1*)5Amc mice
increased lipoma incidence ( J:171821 )
• in 2% of mice
increased lymphoma incidence ( J:171821 )
• in 34% of mice (including T cell, diffuse, anaplastic, and lymph node)
increased sarcoma incidence ( J:171821 )
• in 61% of mice (including angiosarcoma, spindle-cell, giant-cell, and anaplastic)

endocrine/exocrine glands




Genotype
MGI:5000508
ht3
Allelic
Composition		 Trp53tm3.1Glo/Trp53tm4Glo
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (232 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:171821 )
• median survival is 160 days due to tumor development

neoplasm
abnormal tumor morphology ( J:171821 )
• tumors exhibit interstitial inflammatory cells unlike in tumors from Trp53tm3.1Glo/Trp53tm4Glo Tg(CAG-cre/Esr1*)5Amc mice
increased lymphoma incidence ( J:171821 )
• in 60% of mice (including T cell, diffuse, and large cell)
increased sarcoma incidence ( J:171821 )
• in 37% of mice (including angiosarcoma, spindle-cell, and giant-cell)




Genotype
MGI:5000506
cn4
Allelic
Composition		 Trp53tm1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
Trp53tm1Glo mutation (0 available); any Trp53 mutation (232 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:171821 )
• tamoxifen-treated mice survive longer than Trp53tm1Glo/Trp53tm4Glo mice

neoplasm
abnormal tumor pathology ( J:171821 )
• tamoxifen-treated lymphomas exhibit decreased apoptosis response compared with tumors from Trp53tm3.1Glo/Trp53tm4Glo Tg(CAG-cre/Esr1*)5Amc mice
• tamoxifen-treated tumors exhibit decreased cell proliferation compared with control samples
• angiosarcomas treated with tamoxifen exhibit increased senescence compared with tamoxifen-treated angiosarcomas from Trp53tm3.1Glo/Trp53tm4Glo Tg(CAG-cre/Esr1*)5Amc mice
• tamoxifen-treatment induces apoptosis and senescence in giant-cell sarcoma
tumor regression ( J:171821 )
• in tamoxifen-treated mice




Genotype
MGI:5000509
cn5
Allelic
Composition		 Trp53tm3.1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (232 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:171821 )
• tamoxifen-treated mice survive longer than Trp53tm3.1Glo/Trp53tm4Glo mice

neoplasm
abnormal tumor pathology ( J:171821 )
• tamoxifen-treated lymphomas exhibit increased apoptosis response compared with tumors from Trp53tm1Glo/Trp53tm4Glo Tg(CAG-cre/Esr1*)5Amc mice
• 3 of 5 tamoxifen-treated lymphomas exhibit senescence unlike in tumors from Trp53tm1Glo/Trp53tm4Glo Tg(CAG-cre/Esr1*)5Amc mice
• tamoxifen-treated angiosarcomas and lymphomas exhibit senescence
decreased tumor growth/size ( J:171821 )
• tamoxifen-treated mice exhibit little to no tumor growth unlike in control mice




Genotype
MGI:5142304
cx6
Allelic
Composition		 Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm4Glo/Trp53tm4Glo
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm3.1Glo mutation (0 available); any Mdm4 mutation (191 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174368 )
N
• unlike mice homozygous the Mdm4 allele alone, double mutant mice are viable




Genotype
MGI:5000502
cx7
Allelic
Composition		 Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Glo/Trp53tm4Glo
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53tm1Glo mutation (0 available); any Trp53 mutation (232 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
decreased body size ( J:171821 )

behavior/neurological




Genotype
MGI:5000504
cx8
Allelic
Composition		 Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm3.1Glo/Trp53tm4Glo
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (232 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:171821 )
N
• lethality observed in Mdm2tm1Glo homozygotes is completely rescued with mice surviving beyond 5 weeks




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory