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Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan targeted mutation 1, Sean E Egan MGI:5000472 |
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| Summary |
12 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased survival compared to wild-type controls carrying either Tg(MMTV-cre)1Mam or Tg(MMTV-cre)4Mam
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• some mice develop blood vessel lesions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• mice injected intrabursally with an adenovirus expressing cre recombinase (AdCre) exhibit multifocal sites of epithelial hyperplasia in the ovarian surface epithelium
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• mice injected intrabursally with an adenovirus expressing cre recombinase (AdCre) exhibit multifocal sites of epithelial hyperplasia in the ovarian surface epithelium
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice succumb to spontaneous brain tumors
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• tumors are high-grade diffuse gliomas
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• most mice succumb to spontaneous brain tumors
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• tumors are high-grade diffuse gliomas
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| brain glioma | DOID:0060108 | J:285841 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
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• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin
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• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
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• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| brain glioma | DOID:0060108 | J:285841 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most die early with lymphoma/thymoma
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• some mice have small mammary tumors
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• some mice have small mammary tumors
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• some mice have small mammary tumors
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• survival is reduced compared to mutant mice wild-type for Trp53
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• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan
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• at a lower rate than in mutant mice homozygous for Trp53tm1Brn
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• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan
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• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:170898 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• survival time is increased compared to mutant mice carrying Tg(MMTV-cre)1Mam
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• develop a less diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)1Mam
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• start to develop by 5 months of age in both virgin and multiparous mice
• 69% of mice have palpable mammary tumors at the time of death
• tumors are typically either adenosquamous carcinoma or adenomyoepithioma
• isolated lung metastases are seen in rare cases
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• start to develop by 5 months of age in both virgin and multiparous mice
• 69% of mice have palpable mammary tumors at the time of death
• tumors are typically either adenosquamous carcinoma or adenomyoepithioma
• isolated lung metastases are seen in rare cases
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• start to develop by 5 months of age in both virgin and multiparous mice
• 69% of mice have palpable mammary tumors at the time of death
• tumors are typically either adenosquamous carcinoma or adenomyoepithioma
• isolated lung metastases are seen in rare cases
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:170898 | |
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
• mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa rapidly develop primary ovarian tumors
• treatment of isolated tumor cells with the pan-class I PI3K inhibitor, Buparlisib, results in reduced tumor cell viability
• treatment of mice with Buparlisib for 3 weeks starting at week 4 post AdCre injection extends the median latency period of ovarian tumors by 3.5 weeks
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• ovarian tumors of intrabursally AdCre injected mice are predominately solid with some papillary areas, exhibit elongated spindle-shaped cells with vacuolated cytoplasm embedded in hyalinized matrix, appear poorly differentiated and highly disorganized, and have a hobnail appearance, indicating they resemble human ovarian clear-cell carcinoma
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• intrabursally AdCre injected mice exhibit hemorrhagic ascites
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• AdCre treated mice that have tumors exhibit high levels of secreted IL-6 in body fluids and ascitic fluid aspirates
|
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|
• mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa rapidly develop primary ovarian tumors
• treatment of isolated tumor cells with the pan-class I PI3K inhibitor, Buparlisib, results in reduced tumor cell viability
• treatment of mice with Buparlisib for 3 weeks starting at week 4 post AdCre injection extends the median latency period of ovarian tumors by 3.5 weeks
|
|
|
• ovarian tumors of intrabursally AdCre injected mice are predominately solid with some papillary areas, exhibit elongated spindle-shaped cells with vacuolated cytoplasm embedded in hyalinized matrix, appear poorly differentiated and highly disorganized, and have a hobnail appearance, indicating they resemble human ovarian clear-cell carcinoma
|
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• peritoneal metastases are seen in about 50% of mice injected with AdCre in the ovarian bursa
|
|
|
• mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa rapidly develop primary ovarian tumors
• treatment of isolated tumor cells with the pan-class I PI3K inhibitor, Buparlisib, results in reduced tumor cell viability
• treatment of mice with Buparlisib for 3 weeks starting at week 4 post AdCre injection extends the median latency period of ovarian tumors by 3.5 weeks
|
|
|
• ovarian tumors of intrabursally AdCre injected mice are predominately solid with some papillary areas, exhibit elongated spindle-shaped cells with vacuolated cytoplasm embedded in hyalinized matrix, appear poorly differentiated and highly disorganized, and have a hobnail appearance, indicating they resemble human ovarian clear-cell carcinoma
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| ovarian cancer | DOID:2394 |
OMIM:167000 OMIM:607893 |
J:219794 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
• 5 of 7 mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa exhibit ovarian surface epithelium hyperplasia
|
|
|
• 5 of 7 mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa exhibit ovarian surface epithelium hyperplasia
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• survival time is reduced compared to mutant mice carrying Tg(MMTV-cre)4Mam
|
|
• develop a more diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)4Mam
|
|
• start to develop by 5 months of age in both virgin and multiparous mice
• 42% of mice have palpable mammary tumors at the time of death
|
|
• start to develop by 5 months of age in both virgin and multiparous mice
• 42% of mice have palpable mammary tumors at the time of death
|
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• start to develop by 5 months of age in both virgin and multiparous mice
• 42% of mice have palpable mammary tumors at the time of death
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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