Phenotypes associated with this allele

• Allele Symbol: Il17b^{Gt(371C12)Cmhd}
• Allele Name: gene trap 371C12, Centre for Modeling Human Disease
• Allele ID: MGI:4965521
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il17b^Gt(371C12)Cmhd/Il17b^Gt(371C12)Cmhd	B6.129-Il17b^Gt(371C12)Cmhd	MGI:5767206
cx2	Il17b^Gt(371C12)Cmhd/Il17b^Gt(371C12)Cmhd Il25^tm1.1Cdon/Il25^tm1.1Cdon	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5767209

Genotype
MGI:5767206

hm1

• Allelic Composition: Il17b^{Gt(371C12)Cmhd}/Il17b^{Gt(371C12)Cmhd}
• Genetic Background: B6.129-Il17b^{Gt(371C12)Cmhd}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:229778 )

• DSS-treated mice exhibit increased weight loss, inflammation and colon length shortening compared with wild-type mice

increased eosinophil cell number ( J:229778 )

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma

increased T-helper 2 cell number ( J:229778 )

• upon ovalbumin restimulation in mice treated with ovalbumin and alum to induce asthma

abnormal chemokine secretion ( J:229778 )

• increased CCL2 in the colon tissue of DDS-treated mice compared with wild-type mice

abnormal interleukin secretion ( J:229778 )

• increased IL22 in colon tissue of C. rodentium-infected mice

increased interleukin-1 beta secretion ( J:229778 )

• in the colon tissue of DDS-treated mice

increased interleukin-13 secretion ( J:229778 )

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma

decreased interleukin-4 secretion ( J:229778 )

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma

increased interleukin-5 secretion ( J:229778 )

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma

increased interleukin-6 secretion ( J:229778 )

• in the colon tissue of DDS-treated mice

increased tumor necrosis factor secretion ( J:229778 )

• in the colon tissue of DDS-treated mice

increased susceptibility to bacterial infection ( J:229778 )

• Citrobacter rodentium-infected mice exhibit mild weight loss and increased fecal bacterial burden and bacterial load in the liver and spleen compared with wild-type mice

digestive/alimentary system

increased susceptibility to induced colitis ( J:229778 )

• DSS-treated mice exhibit increased weight loss, inflammation and colon length shortening compared with wild-type mice

growth/size/body

increased susceptibility to weight loss ( J:229778 )

• in DSS-treated mice

• Citrobacter rodentium-infected mice exhibit mild weight loss compared with wild-type mice

hematopoietic system

increased eosinophil cell number ( J:229778 )

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma

increased T-helper 2 cell number ( J:229778 )

• upon ovalbumin restimulation in mice treated with ovalbumin and alum to induce asthma

Genotype
MGI:5767209

cx2

• Allelic Composition: Il17b^{Gt(371C12)Cmhd}/Il17b^{Gt(371C12)Cmhd}; Il25^tm1.1Cdon/Il25^tm1.1Cdon
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

immune system

immune system phenotype ( J:229778 )

N • unlike either single homozygote, DSS-treated mice exhibit normal weight loss and colon inflammation

N • Citrobacter rodentium-infected mice exhibit normal IL22 in colon tissue

N • mice treated with ovalbumin and alum to induce asthma exhibit normal Th2 cell cytokine production

digestive/alimentary system

digestive/alimentary phenotype ( J:229778 )

N • unlike either single homozygote, DSS-treated mice exhibit normal weight loss and colon inflammation