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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Vil1-PPARGC1A)#Amos
transgene insertion, Antonio Moschetta
MGI:4950744
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		ApcMin/Apc+
Tg(Vil1-PPARGC1A)#Amos/0 		involves: C57BL/6J * FVB/N MGI:4950747
tg2
 		Tg(Vil1-PPARGC1A)#Amos/0 involves: FVB/N MGI:4950746


Genotype
MGI:4950747
cx1
Allelic
Composition		 ApcMin/Apc+
Tg(Vil1-PPARGC1A)#Amos/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Tg(Vil1-PPARGC1A)#Amos mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased alimentary system tumor incidence ( J:171361 )
• fewer intestinal tumors form than in controls
• tumors are smaller in size than in controls
decreased tumor growth/size ( J:171361 )
• fewer intestinal tumors form
• average size of intestinal tumors is reduced
• higher apoptosis rates in intestinal tumors

digestive/alimentary system
decreased alimentary system tumor incidence ( J:171361 )
• fewer intestinal tumors form than in controls
• tumors are smaller in size than in controls




Genotype
MGI:4950746
tg2
Allelic
Composition		 Tg(Vil1-PPARGC1A)#Amos/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased mitochondrial number ( J:171361 )
• increased number of mitochondria in apical enterocytes
increased enterocyte apoptosis ( J:171361 )
• higher numbers of apoptotic cells on the entire surface of villi

digestive/alimentary system
increased enterocyte apoptosis ( J:171361 )
• higher numbers of apoptotic cells on the entire surface of villi
abnormal crypts of Lieberkuhn morphology ( J:171361 )
• villi and crypts are visibly shorter than in controls
decreased small intestinal villus height ( J:171361 )
• villi are visibly shorter than in controls

neoplasm
decreased incidence of tumors by chemical induction ( J:171361 )
• fewer tumors are induced using azoxymethane and dextran sodium sulfate than in controls
• induced tumors are smaller (4mm3) than in controls (15mm3)
decreased tumor growth/size ( J:171361 )
• fewer tumors are induced using azoxymethane and dextran sodium sulfate than in controls
• induced tumors are smaller (4mm3) than in controls (15mm3)

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:171361 )
• villi and crypts are visibly shorter than in controls

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:171361 )
• fewer tumors are induced using azoxymethane and dextran sodium sulfate than in controls
• induced tumors are smaller (4mm3) than in controls (15mm3)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory