Phenotypes associated with this allele

• Allele Symbol: Esr1^tm1.1Ohl
• Allele Name: targeted mutation 1.1, Claes Ohlsson
• Allele ID: MGI:4950046
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esr1^tm1.1Ohl/Esr1^tm1.1Ohl	involves: 129S2/SvPas	MGI:5577258
hm2	Esr1^tm1.1Ohl/Esr1^tm1.1Ohl	involves: 129S2/SvPas * C57BL/6	MGI:4950052

Genotype
MGI:5577258

hm1

• Allelic Composition: Esr1^tm1.1Ohl/Esr1^tm1.1Ohl
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:206373 )

N • estradiol- or estrogen-macromolecule conjugates-treatment stimulates endothelial repair following carotid injury in a similar manner as in wild-type controls

Genotype
MGI:4950052

hm2

• Allelic Composition: Esr1^tm1.1Ohl/Esr1^tm1.1Ohl
• Genetic Background: involves: 129S2/SvPas * C57BL/6

homeostasis/metabolism

increased circulating testosterone level ( J:171276 )

• in female mice

increased circulating estradiol level ( J:171276 )

• in female mice

increased circulating luteinizing hormone level ( J:171276 )

• in female mice

abnormal response/metabolism to endogenous compounds ( J:171276 )

• estradiol-treated, ovariectomized mice fail to exhibit an affect on total body areal bone mineral density (aBMD), trabecular bone parameters (trabecular bone volume and trabecular number), cortical bone parameters, bone marrow parameters, non-bone parameters (uterus, thymus, and liver weights), or Ig secretion unlike similarly treated wild-type mice

immune system

abnormal thymus physiology ( J:171276 )

• estradiol-treated, ovariectomized mice fail to exhibit a decrease in thymus weight unlike similarly treated wild-type mice

abnormal immunoglobulin level ( J:171276 )

• estradiol-treated, ovariectomized mice fail to exhibit an increase in IgG, IgM, and IgA secretion unlike in similarly treated wild-type mice

skeleton

abnormal skeleton physiology ( J:171276 )

• estradiol-treated, ovariectomized mice fail to exhibit an increase in total body areal bone mineral density (aBMD), trabecular bone parameters (trabecular bone volume and trabecular number), and cortical bone parameters unlike similarly treated wild-type mice

hematopoietic system

abnormal thymus physiology ( J:171276 )

• estradiol-treated, ovariectomized mice fail to exhibit a decrease in thymus weight unlike similarly treated wild-type mice

abnormal immunoglobulin level ( J:171276 )

• estradiol-treated, ovariectomized mice fail to exhibit an increase in IgG, IgM, and IgA secretion unlike in similarly treated wild-type mice

abnormal bone marrow cell physiology ( J:171276 )

• estradiol-treated, ovariectomized mice fail to exhibit a decrease in bone marrow cellularity and B lymphocytes unlike similarly treated wild-type mice

endocrine/exocrine glands

abnormal thymus physiology ( J:171276 )

• estradiol-treated, ovariectomized mice fail to exhibit a decrease in thymus weight unlike similarly treated wild-type mice