Esr1^tm1.1Ohl
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1.1Ohl
• Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Claes Ohlsson
• MGI ID: MGI:4950046
• Synonyms: ERalphaAF-2⁰
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1.1Ohl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171276
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutation: Intragenic deletion
• Mutation details: Mice lack the sequence in exon 8 that encodes the AF-2 core (amino acids 543 to 549; LLLEMLD). A floxed neo cassette used for selection was removed by cre-mediated recombination. The expression of a slightly smaller protein was confirmed by western blot analysis on uterus extracts. (J:171276, J:175619, J:206373)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 67 strains or lines available

References

• Original: J:171276 Borjesson AE, et al., Roles of transactivating functions 1 and 2 of estrogen receptor-{alpha} in bone. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6288-93
• All: 10 reference(s)