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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Hhex-EGFP)#Rbe
transgene insertion, Rosa S P Beddington
MGI:4949257
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Lefty1tm1Hmd/Lefty1tm1Hmd
Tg(Hhex-EGFP)#Rbe/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA/J MGI:4949262
cx2
 		Pignm1Nisw/Pignm1Nisw
Tg(Hhex-EGFP)#Rbe/0 		involves: 129S1/SvImJ * C3H/HeJ * CBA/J * C57BL/6 * C57BL/6J MGI:6361208
cx3
 		Pgap1m1Nisw/Pgap1m1Nisw
Tg(Hhex-EGFP)#Rbe/0 		involves: C57BL/6 * C57BL/6J * CBA/J MGI:6361209
cx4
 		Pold1tyrn/Pold1tyrn
Tg(Hhex-EGFP)#Rbe/0 		involves: C57BL/6 * C57BL/6J * CBA/J MGI:7467523
cx5
 		Rac1tm2Tyb/Rac1tm2Tyb
Tg(Hhex-EGFP)#Rbe/0 		mixed MGI:5050122


Genotype
MGI:4949262
cx1
Allelic
Composition		 Lefty1tm1Hmd/Lefty1tm1Hmd
Tg(Hhex-EGFP)#Rbe/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lefty1tm1Hmd mutation (1 available); any Lefty1 mutation (41 available)
Tg(Hhex-EGFP)#Rbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal anterior visceral endoderm cell migration ( J:170681 )
• 5 of 7 mice exhibit an anterior visceral endoderm (AVE) migration defect (1 arrested migration; 4 over-migration) compared with wild-type mice
• 5 of 13 mice exhibit mild AVE migration defects (1 slight delay; 4 slight over-migration) compared with wild-type mice

cellular
abnormal anterior visceral endoderm cell migration ( J:170681 )
• 5 of 7 mice exhibit an anterior visceral endoderm (AVE) migration defect (1 arrested migration; 4 over-migration) compared with wild-type mice
• 5 of 13 mice exhibit mild AVE migration defects (1 slight delay; 4 slight over-migration) compared with wild-type mice




Genotype
MGI:6361208
cx2
Allelic
Composition		 Pignm1Nisw/Pignm1Nisw
Tg(Hhex-EGFP)#Rbe/0
Genetic
Background		 involves: 129S1/SvImJ * C3H/HeJ * CBA/J * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pignm1Nisw mutation (1 available); any Pign mutation (68 available)
Tg(Hhex-EGFP)#Rbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular

embryo
abnormal anterior definitive endoderm morphology ( J:187360 )
• E7.5 embryos exhibit a modest displacement of the anterior definitive endoderm towards the distal tip compared to wild-type embryos
abnormal anterior visceral endoderm morphology ( J:187360 )
• E6.5 embryos exhibit aberrant distal visceral endoderm/anterior visceral endoderm localization, with a displacement at the distal tip
abnormal distal visceral endoderm morphology ( J:187360 )
• E6.5 embryos exhibit aberrant distal visceral endoderm/anterior visceral endoderm localization, with a displacement at the distal tip




Genotype
MGI:6361209
cx3
Allelic
Composition		 Pgap1m1Nisw/Pgap1m1Nisw
Tg(Hhex-EGFP)#Rbe/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgap1m1Nisw mutation (1 available); any Pgap1 mutation (53 available)
Tg(Hhex-EGFP)#Rbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular

embryo
abnormal anterior definitive endoderm morphology ( J:187360 )
• E7.5 embryos exhibit a modest displacement of the anterior definitive endoderm towards the distal tip compared to wild-type embryos
abnormal anterior visceral endoderm morphology ( J:187360 )
• E6.5 embryos exhibit aberrant distal visceral endoderm/anterior visceral endoderm localization, with an expanded population throughout the visceral endoderm
abnormal distal visceral endoderm morphology ( J:187360 )
• E6.5 embryos exhibit aberrant distal visceral endoderm/anterior visceral endoderm localization, with an expanded population throughout the visceral endoderm




Genotype
MGI:7467523
cx4
Allelic
Composition		 Pold1tyrn/Pold1tyrn
Tg(Hhex-EGFP)#Rbe/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1tyrn mutation (0 available); any Pold1 mutation (62 available)
Tg(Hhex-EGFP)#Rbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:327432 )
N
• normal anterior-posterior (A-P) patterning in E8.5 embryos
• normal anterior visceral endoderm positioning in E6.5 embryos
abnormal primitive streak elongation ( J:327432 )
• failure of primitive streak to extend to the distal tip in E7.5 embryos
• severe deficiency of allantois mesoderm in E7.5 embryos
• aberrantly positioned anterior definitive endoderm (ADE) and axial mesoderm (AME) in E7.5 embryos
abnormal allantois morphology ( J:327432 )
• severe deficiency of allantois mesoderm in E7.5 embryos




Genotype
MGI:5050122
cx5
Allelic
Composition		 Rac1tm2Tyb/Rac1tm2Tyb
Tg(Hhex-EGFP)#Rbe/0
Genetic
Background		 mixed
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac1tm2Tyb mutation (0 available); any Rac1 mutation (21 available)
Tg(Hhex-EGFP)#Rbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal anterior visceral endoderm cell migration ( J:166095 )
• anterior visceral endoderm cells fail to migrate from the distal tip to the embryonic-extraembryonic boundary by E6.5
• between E5.5 and E5.75 some cells lose contact with the basement membrane
• at E6.5 cells that fail to migrate form a multilayered epithelium

cellular
abnormal anterior visceral endoderm cell migration ( J:166095 )
• anterior visceral endoderm cells fail to migrate from the distal tip to the embryonic-extraembryonic boundary by E6.5
• between E5.5 and E5.75 some cells lose contact with the basement membrane
• at E6.5 cells that fail to migrate form a multilayered epithelium




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory