All Phenotypes Rr117<tm1.1Dje> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rr117^tm1.1Dje
targeted mutation 1.1, Douglas J Epstein
MGI:4948508

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr117^tm1.1Dje/Rr117^tm1.1Dje	involves: 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N	MGI:4948510
cx2	Rr117^tm1.1Dje/Rr117⁺ Shh^tm1Amc/Shh⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N	MGI:4948512

Allelic Composition	Rr117^tm1.1Dje/Rr117^tm1.1Dje
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:170540 )

N	• no gross morphological defects in the brain

Allelic Composition	Rr117^tm1.1Dje/Rr117⁺ Shh^tm1Amc/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr117^tm1.1Dje mutation (0 available); any Rr117 mutation (0 available)
Shh^tm1Amc mutation (1 available); any Shh mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:170540 )

• 80% of mice fail to gain weight and die by 7 days of age

• 20% survive to adulthood

growth/size/body

slow postnatal weight gain ( J:170540 )

• normal weight at birth

• 80% fail to gain weight after birth and die by 7 days of age

• the 20% who survive remain remain small, 33% of normal weight

behavior/neurological

behavior/neurological phenotype ( J:170540 )

N	• normal suckling response • dead pups often have milk in their stomach • well coordinated motor control

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:170540 )

N	• normal blood glucose

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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