Analysis Tools
vision/eye
|
• eye examination at 12 weeks of age revealed deep anterior chambers
|
|
Allele Symbol Allele Name Allele ID |
Tdrd7nmf166 neuroscience mutagenesis facility, 166 MGI:4943539 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• eye examination at 12 weeks of age revealed deep anterior chambers
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are seen
|
|
• iris flattening is detected by 4 months of age
|
|
• increased depth is seen by 4 months of age
|
|
• lens extrusion at later stages
• in some cases the mass of fiber cells pass through the pupil into the anterior chamber of the eye
|
|
• rupture and extrusion of fiber cell mass into the vitreous at later stages
|
|
• develop vacuoles at later stages
|
|
• all develop posterior cataracts by 4 weeks of age that become more severe with age
|
|
• detected in some mice by 6 months of age
• incidence increases with age
|
 |
• arrests at the round spermatid stage
|
|
• severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are seen
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/14/2024 MGI 6.23 |
|
|
|
||