All Phenotypes Pcsk9<tm1.1Prat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pcsk9^tm1.1Prat
targeted mutation 1.1, Annik Prat
MGI:4943284

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pcsk9^tm1.1Prat/Pcsk9^tm1.1Prat Speer6-ps1^{Tg(Alb-cre)21Mgn}/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	MGI:4943540

Allelic Composition	Pcsk9^tm1.1Prat/Pcsk9^tm1.1Prat Speer6-ps1^{Tg(Alb-cre)21Mgn}/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcsk9^tm1.1Prat mutation (1 available); any Pcsk9 mutation (44 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:169834 )

• total plasma cholesterol reduced 27%

decreased circulating HDL cholesterol level ( J:169834 )

• plasma levels are 70% of levels in controls

decreased circulating LDL cholesterol level ( J:169834 )

• plasma levels are 40% of levels in controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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