All Phenotypes Tg(Mt1-CETP)#Tall MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Mt1-CETP)#Tall
transgene insertion, Alan Tall
MGI:4941577

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoa1^tm1Bres/Apoa1^tm1Bres Tg(Mt1-CETP)#Tall/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:4941578
cx2	Ldlr^tm1Her/Ldlr^tm1Her Tg(APOC3)3707Bres/? Tg(Mt1-CETP)#Tall/?	involves: 129S7/SvEvBrd * C57BL/6J * CBA/J	MGI:4941579

Allelic Composition	Apoa1^tm1Bres/Apoa1^tm1Bres Tg(Mt1-CETP)#Tall/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1^tm1Bres mutation (0 available); any Apoa1 mutation (16 available)
Tg(Mt1-CETP)#Tall mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a further 44% reduction in HDL-C levels compared to in Apoa1^tm1Bres homozygotes

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Tg(APOC3)3707Bres/? Tg(Mt1-CETP)#Tall/?
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (21 available); any Ldlr mutation (78 available)
Tg(APOC3)3707Bres mutation (1 available)
Tg(Mt1-CETP)#Tall mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:37861 )

• lowered by 79% on a normal diet

• lowered by 36% on a Western diet

• cholesterol shifted from HDL to IDL-LDL and VLDL

increased circulating LDL cholesterol level ( J:37861 )

• cholesterol shifted from HDL to IDL-LDL and VLDL

increased circulating VLDL cholesterol level ( J:37861 )

• cholesterol shifted from HDL to IDL-LDL and VLDL

increased circulating triglyceride level ( J:37861 )

• triglycerides shifted from VLDL to IDL-LDL and HDL

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