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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nogtm1.1Rmh
targeted mutation 1.1, Richard M Harland
MGI:4941468
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Grem1tm1Ecan/Grem1tm1Ecan
Nogtm1.1Rmh/Nogtm1.1Rmh
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:4941475
cn2
 		Grem1tm1Ecan/Grem1+
Nogtm1.1Rmh/Nogtm1.1Rmh
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:4941476
cn3
 		Nogtm1.1Rmh/Nogtm1.1Rmh
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:4941474


Genotype
MGI:4941475
cn1
Allelic
Composition		 Grem1tm1Ecan/Grem1tm1Ecan
Nogtm1.1Rmh/Nogtm1.1Rmh
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1tm1Ecan mutation (0 available); any Grem1 mutation (19 available)
Nogtm1.1Rmh mutation (1 available); any Nog mutation (18 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
open neural tube ( J:169133 )
• the neural tube and brain fail to fuse dorsally unlike in wild-type mice
abnormal somite development ( J:169133 )
• mice exhibit disorganized somites compared with wild-type mice
decreased somite size ( J:169133 )
• mice exhibit small somites compared with wild-type mice

nervous system
open neural tube ( J:169133 )
• the neural tube and brain fail to fuse dorsally unlike in wild-type mice
abnormal brain development ( J:169133 )
• development anterior to the midbrain is arrested

skeleton
absent sclerotome ( J:169133 )
• mice lack sclerotome compared with wild-type mice
• however, cell death and proliferation is normal

limbs/digits/tail

growth/size/body
abnormal head development ( J:169133 )
• mice exhibit abnormal head development compared with wild-type mice




Genotype
MGI:4941476
cn2
Allelic
Composition		 Grem1tm1Ecan/Grem1+
Nogtm1.1Rmh/Nogtm1.1Rmh
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1tm1Ecan mutation (0 available); any Grem1 mutation (19 available)
Nogtm1.1Rmh mutation (1 available); any Nog mutation (18 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube morphology ( J:169133 )
• at E8.5 and E9.5, mice exhibit buckled neural tubes that frequently fail to close anteriorly unlike in wild-type mice
open neural tube ( J:169133 )
• anteriorly in some mice

embryo
abnormal neural tube morphology ( J:169133 )
• at E8.5 and E9.5, mice exhibit buckled neural tubes that frequently fail to close anteriorly unlike in wild-type mice
open neural tube ( J:169133 )
• anteriorly in some mice
decreased somite size ( J:169133 )
• at E8.5 and E9.5, mice exhibit small posterior somites compared with wild-type mice




Genotype
MGI:4941474
cn3
Allelic
Composition		 Nogtm1.1Rmh/Nogtm1.1Rmh
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nogtm1.1Rmh mutation (1 available); any Nog mutation (18 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal rib morphology ( J:169133 )
• mice exhibit thickened ribs compared with wild-type mice
abnormal vertebrae morphology ( J:169133 )
• mice exhibit thickened vertebrae to approximately the anterior-posterior level of the twelfth to fifteenth vertebra compared with wild-type mice
abnormal cartilage morphology ( J:169133 )
• mice exhibit reduced or absent axial cartilage compared with wild-type mice
abnormal skeleton development ( J:169133 )
• mice exhibit thickened cervical and thoracic skeletal elements and reduced lumbar cartilage compared with wild-type mice
abnormal cartilage development ( J:169133 )
• mice exhibit dysmorphic condensation at the level of the hind limb compared with wild-type mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory