Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm2(myc*T58A)Rcse}
• Allele Name: targeted mutation 2, Rosalie C Sears
• Allele ID: MGI:4941057
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(myc*T58A)Rcse/Gt(ROSA)26Sor^tm2(myc*T58A)Rcse Tg(Wap-cre)11738Mam/0	involves: 129 * C57BL/6 * SJL	MGI:4941160

Genotype
MGI:4941160

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2(myc*T58A)Rcse}/Gt(ROSA)26Sor^{tm2(myc*T58A)Rcse}; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased pituitary gland tumor incidence ( J:169403 )

increased brain tumor incidence ( J:169403 )

• 24 of 28 mice succumb to brain tumors (pituitary tumors and choroid plexus tumors) with a latency of 46 weeks

mortality/aging

decreased tumor-free survival time ( J:169403 )

• 24 of 28 mice succumb to brain tumors with a median survival of 46 weeks

neoplasm

increased mammary adenocarcinoma incidence ( J:169403 )

• 4 of 28 mice develop mammary tumors with a latency of 38 weeks

increased pituitary gland tumor incidence ( J:169403 )

increased brain tumor incidence ( J:169403 )

• 24 of 28 mice succumb to brain tumors (pituitary tumors and choroid plexus tumors) with a latency of 46 weeks

cellular

aneuploidy ( J:169403 )

• in mammary epithelial cells

polyploidy ( J:169403 )

• in mammary epithelial cells

chromosomal instability ( J:169403 )

• mammary epithelial cells exhibit increased chromosomal instability with high rates of polyploidy and aneuploidy compared with control cells

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:169403 )

♀ • mammary ductal branching and alveolar budding are increased compared to in control mice

abnormal involution of the mammary gland ( J:169403 )

♀ • delayed and incomplete with reduced apoptosis

abnormal mammary gland alveolus morphology ( J:169403 )

♀ • alveolar structures exhibit disorganization and reduced adhesion compared to in control mice

mammary gland alveolar hyperplasia ( J:169403 )

♀ • parous mice exhibit expanded alveolar regions with enlarged ducts and increased stromal and epithelial cells compared with control mice

increased mammary adenocarcinoma incidence ( J:169403 )

• 4 of 28 mice develop mammary tumors with a latency of 38 weeks

mammary gland hyperplasia ( J:169403 )

♀ • at 5 to 8 months, parous mice exhibit hyperplastic foci in the mammary gland unlike control mice

increased pituitary gland tumor incidence ( J:169403 )

abnormal mammary gland epithelium physiology ( J:169403 )

♀ • apoptosis of mammary gland epithelium during involution is decreased compared to in control mice

integument

abnormal branching of the mammary ductal tree ( J:169403 )

♀ • mammary ductal branching and alveolar budding are increased compared to in control mice

abnormal involution of the mammary gland ( J:169403 )

♀ • delayed and incomplete with reduced apoptosis

abnormal mammary gland alveolus morphology ( J:169403 )

♀ • alveolar structures exhibit disorganization and reduced adhesion compared to in control mice

mammary gland alveolar hyperplasia ( J:169403 )

♀ • parous mice exhibit expanded alveolar regions with enlarged ducts and increased stromal and epithelial cells compared with control mice

increased mammary adenocarcinoma incidence ( J:169403 )

• 4 of 28 mice develop mammary tumors with a latency of 38 weeks

mammary gland hyperplasia ( J:169403 )

♀ • at 5 to 8 months, parous mice exhibit hyperplastic foci in the mammary gland unlike control mice

abnormal mammary gland epithelium physiology ( J:169403 )

♀ • apoptosis of mammary gland epithelium during involution is decreased compared to in control mice