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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mef2c-cre)#Blk
transgene insertion, Brian L Black
MGI:4940068
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		\Hand2tm1Dsr/\Hand2tm2.1Dsr
\Tg(Mef2c-cre)#Blk/0 		involves: 129 * 129S7/SvEvBrd * C57BL/6 MGI:4940093
cn2
 		\Nkx2-5tm1Krc/\Nkx2-5tm1Krc
\Tg(Mef2c-cre)#Blk/0 		involves: 129 * C57BL/6 MGI:5643690
cn3
 		\Arhgef25tm1.1Xya/\Arhgef25tm1.1Xya
\Tg(Mef2c-cre)#Blk/0 		involves: 129S4/SvJaeSor * C57BL/6 MGI:5426697
cn4
 		\Irx3tm3Hui/\Irx3tm3Hui
\Irx5tm3Hui/\Irx5tm3Hui
\Tg(Mef2c-cre)#Blk/0 		Not Specified MGI:5444487
cn5
 		\Zic3tm1.1Smwa/Y
\Tg(Mef2c-cre)#Blk/0 		Not Specified MGI:5476841


Genotype
MGI:4940093
cn1
Allelic
Composition		 \Hand2tm1Dsr/\Hand2tm2.1Dsr
\Tg(Mef2c-cre)#Blk/0
Genetic
Background		 involves: 129 * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Dsr mutation (0 available); any Hand2 mutation (13 available)
Hand2tm2.1Dsr mutation (0 available); any Hand2 mutation (13 available)
Tg(Mef2c-cre)#Blk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
persistent truncus arteriosus ( J:169213 )
• immature truncus arteriosis
abnormal tricuspid valve morphology ( J:169213 )
• mice lack the anlage of the tricuspid valve between the right atrium and ventricle unlike wild-type mice
decreased heart right ventricle size ( J:169213 )
• at E9.5 but not as severely as in Hand2tm1Dsr homozygotes

muscle




Genotype
MGI:5643690
cn2
Allelic
Composition		 \Nkx2-5tm1Krc/\Nkx2-5tm1Krc
\Tg(Mef2c-cre)#Blk/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm1Krc mutation (0 available); any Nkx2-5 mutation (22 available)
Tg(Mef2c-cre)#Blk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:214093 )
• early embryonic lethality at E10-E10.5

cardiovascular system
abnormal cardiac outflow tract development ( J:214093 )
• foreshortened outflow tract
absent heart right ventricle ( J:214093 )
• loss of right ventricle




Genotype
MGI:5426697
cn3
Allelic
Composition		 \Arhgef25tm1.1Xya/\Arhgef25tm1.1Xya
\Tg(Mef2c-cre)#Blk/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef25tm1.1Xya mutation (0 available); any Arhgef25 mutation (37 available)
Tg(Mef2c-cre)#Blk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:183551 )
N
• mice are born in the expected Mendelian ratio

cardiovascular system
cardiovascular system phenotype ( J:183551 )
N
• mice exhibit normal development of the second heart field




Genotype
MGI:5444487
cn4
Allelic
Composition		 \Irx3tm3Hui/\Irx3tm3Hui
\Irx5tm3Hui/\Irx5tm3Hui
\Tg(Mef2c-cre)#Blk/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3tm3Hui mutation (0 available); any Irx3 mutation (26 available)
Irx5tm3Hui mutation (0 available); any Irx5 mutation (31 available)
Tg(Mef2c-cre)#Blk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:189007 )
• recapitulates outflow tract abnormalities seen in germ line double null mice




Genotype
MGI:5476841
cn5
Allelic
Composition		 \Zic3tm1.1Smwa/Y
\Tg(Mef2c-cre)#Blk/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mef2c-cre)#Blk mutation (0 available)
Zic3tm1.1Smwa mutation (0 available); any Zic3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:194989 )
• viable with no cardiac looping defects detected




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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory