All Phenotypes Kit<tm1Rosay> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kit^tm1Rosay
targeted mutation 1, Kenton M Sanders and Seungil Ro
MGI:4939904

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kit^tm1Rosay/Kit^tm1Rosay	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4940017
ht2	Kit^tm1Rosay/Kit⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4940018
cx3	Kit^tm1Rosay/Kit⁺ Lep^ob/Lep^ob	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4940020

Allelic Composition	Kit^tm1Rosay/Kit^tm1Rosay
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^tm1Rosay mutation (1 available); any Kit mutation (177 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:168676 )

• mice do not survive to birth

Allelic Composition	Kit^tm1Rosay/Kit⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^tm1Rosay mutation (1 available); any Kit mutation (177 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

white spotting ( J:168676 )

• mice exhibit white patches at the end of the tail and on the belly and white paws compared with wild-type mice

belly spot ( J:168676 )

pigmentation

white spotting ( J:168676 )

• mice exhibit white patches at the end of the tail and on the belly and white paws compared with wild-type mice

belly spot ( J:168676 )

Allelic Composition	Kit^tm1Rosay/Kit⁺ Lep^ob/Lep^ob
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^tm1Rosay mutation (1 available); any Kit mutation (177 available)
Lep^ob mutation (5 available); any Lep mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal interstitial cell of Cajal morphology ( J:168676 )

• interstitial cells of Cajal networks are disrupted during the development of diabetes unlike in Kit^tm1Rosan heterozygotes

• mice exhibit loss of interstitial cells of Cajal unlike Kit^tm1Rosan heterozygotes

growth/size/body

obese ( J:168676 )

• by 4 to 6 weeks of age

homeostasis/metabolism

hyperglycemia ( J:168676 )

• by 10 to 12 weeks of age

integument

white spotting ( J:168676 )

• mice exhibit white paws and tail unlike wild-type mice

pigmentation

white spotting ( J:168676 )

• mice exhibit white paws and tail unlike wild-type mice

cellular

abnormal interstitial cell of Cajal morphology ( J:168676 )

• interstitial cells of Cajal networks are disrupted during the development of diabetes unlike in Kit^tm1Rosan heterozygotes

• mice exhibit loss of interstitial cells of Cajal unlike Kit^tm1Rosan heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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