Phenotypes associated with this allele

• Allele Symbol: Mycbp2^tm1.1Klsc
• Allele Name: targeted mutation 1.1, Klaus Scholich
• Allele ID: MGI:4939601
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mycbp2^tm1.1Klsc/Mycbp2^tm1.1Klsc Tg(Scn10a-cre)1Rkun/0	involves: C57BL/6 * DBA/2	MGI:4939606
cn2	Mycbp2^tm1.1Klsc/Mycbp2^tm1.1Klsc Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:4939605

Genotype
MGI:4939606

cn1

• Allelic Composition: Mycbp2^tm1.1Klsc/Mycbp2^tm1.1Klsc; Tg(Scn10a-cre)1Rkun/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal spinal cord morphology ( J:168745 )

• the medial region of lamina II is enlarged in the spinal cord compared with wild-type mice

behavior/neurological

decreased thermal nociceptive threshold ( J:168745 )

• mice exhibit prolonged formalin-induced hyperphagia compared with wild-type mice

• however, mice exhibit normal mustard oil-induced desensitization and behavioral response to mechanical stimuli

Genotype
MGI:4939605

cn2

• Allelic Composition: Mycbp2^tm1.1Klsc/Mycbp2^tm1.1Klsc; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

mortality/aging

abnormal survival ( J:168745 )

• mice exhibit a lethal phenotype (no time point of death given)