Phenotypes associated with this allele

• Allele Symbol: Rmi1^{Gt(pUHachi)0283Imeg}
• Allele Name: gene trap 0283, Institute of Molecular Embryology and Genetics
• Allele ID: MGI:4936755
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rmi1^Gt(pUHachi)0283Imeg/Rmi1^Gt(pUHachi)0283Imeg	involves: C57BL/6	MGI:4936831
ht2	Rmi1^Gt(pUHachi)0283Imeg/Rmi1^+	involves: C57BL/6	MGI:4936832
cx3	A^y/a Rmi1^Gt(pUHachi)0283Imeg/Rmi1^+	involves: C57BL/6 * KK	MGI:4936833
cx4	a/a Rmi1^Gt(pUHachi)0283Imeg/Rmi1^+	involves: C57BL/6 * KK	MGI:4936834

Genotype
MGI:4936831

hm1

• Allelic Composition: Rmi1^{Gt(pUHachi)0283Imeg}/Rmi1^{Gt(pUHachi)0283Imeg}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:168271 )

• all embryos die (no time point given)

Genotype
MGI:4936832

ht2

• Allelic Composition: Rmi1^{Gt(pUHachi)0283Imeg}/Rmi1⁺
• Genetic Background: involves: C57BL/6

growth/size/body

decreased body weight ( J:168271 )

decreased susceptibility to diet-induced obesity ( J:168271 )

• when fed a high-fat diet, mice gain less weight and less intra-gonadal fat compared with wild-type mice

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:168271 )

• when fed a high-fat diet, mice gain less weight and less intra-gonadal fat compared with wild-type mice

decreased circulating glucose level ( J:168271 )

• in fasted mice

abnormal glucose tolerance ( J:168271 )

• when fed a high-fat diet, mice do not exhibit impaired glucose tolerance unlike wild-type mice

behavior/neurological

decreased food intake ( J:168271 )

• when fed a high-fat diet

adipose tissue

decreased gonadal fat pad weight ( J:168271 )

• when fed a high-fat diet

Genotype
MGI:4936833

cx3

• Allelic Composition: A^y/a; Rmi1^{Gt(pUHachi)0283Imeg}/Rmi1⁺
• Genetic Background: involves: C57BL/6 * KK

growth/size/body

decreased body weight ( J:168271 )

• compared with A^y/a mice

homeostasis/metabolism

decreased circulating glucose level ( J:168271 )

• compared with A^y/a mice

improved glucose tolerance ( J:168271 )

• compared with A^y/a mice

behavior/neurological

abnormal eating behavior ( J:168271 )

• compared with A^y/a mice

liver/biliary system

decreased liver weight ( J:168271 )

• compared with A^y/a mice

adipose tissue

adipose tissue phenotype ( J:168271 )

N • mice exhibit normal intra-abdominal fat

Genotype
MGI:4936834

cx4

• Allelic Composition: a/a; Rmi1^{Gt(pUHachi)0283Imeg}/Rmi1⁺
• Genetic Background: involves: C57BL/6 * KK

growth/size/body

decreased body weight ( J:168271 )

• compared with a/a homozygotes

homeostasis/metabolism

decreased circulating glucose level ( J:168271 )

• compared with a/a homozygotes

improved glucose tolerance ( J:168271 )

• compared with a/a homozygotes

liver/biliary system

decreased liver weight ( J:168271 )

• compared with a/a homozygotes

adipose tissue

decreased gonadal fat pad weight ( J:168271 )

• compared with a/a homozygotes

behavior/neurological

behavior/neurological phenotype ( J:168271 )

N • mice exhibit normal food intake