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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpa33tm1(GNAS)Wtsi
targeted mutation 1, Wellcome Trust Sanger Institute
MGI:4889205
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/? 		involves: 129S7/SvEvBrd * C57BL/6J MGI:4889208
cn2
 		ApcMin/Apc+
Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/? 		involves: 129S7/SvEvBrd * C57BL/6J MGI:4889209


Genotype
MGI:4889208
cn1
Allelic
Composition		 Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpa33tm1(GNAS)Wtsi mutation (0 available); any Gpa33 mutation (137 available)
Hprt1tm1(CMV-cre)Brd mutation (0 available); any Hprt1 mutation (1274 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:168378 )
N
• mice do not develop intestinal polyps




Genotype
MGI:4889209
cn2
Allelic
Composition		 ApcMin/Apc+
Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Gpa33tm1(GNAS)Wtsi mutation (0 available); any Gpa33 mutation (137 available)
Hprt1tm1(CMV-cre)Brd mutation (0 available); any Hprt1 mutation (1274 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:168378 )
• compared with ApcMin heterozygotes

digestive/alimentary system
increased intestinal adenoma incidence ( J:168378 )
• compared with ApcMin heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory