All Phenotypes Akt2<tm1.2Mbb> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akt2^tm1.2Mbb
targeted mutation 1.2, Morris J Birnbaum
MGI:4889113

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Tg(Alb1-cre)1Khk/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL	MGI:4889114
cn2	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Lep^ob/Lep^ob Tg(Alb1-cre)1Khk/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL	MGI:4889115

Allelic Composition	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Tg(Alb1-cre)1Khk/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.2Mbb mutation (1 available); any Akt2 mutation (54 available)
Tg(Alb1-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased liver triglyceride level ( J:155432 )

• in fed mice fed a Surwit high-fat diet at 1 and 4 months

growth/size/body

growth/size/body region phenotype ( J:155432 )

N	• mice exhibit normal body weight and susceptibility to diet-induced obesity

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• in fed mice fed a Surwit high-fat diet at 1 and 4 months

Allelic Composition	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Lep^ob/Lep^ob Tg(Alb1-cre)1Khk/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.2Mbb mutation (1 available); any Akt2 mutation (54 available)
Lep^ob mutation (5 available); any Lep mutation (20 available)
Tg(Alb1-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:155432 )

• fasted mice exhibit increased plasma glucose levels compared with Akt2^tm1Mbb Lep^ob homozygotes

abnormal lipid homeostasis ( J:155432 )

• mice exhibit reduced lipogenesis compared to in Akt2^tm1Mbb Lep^ob homozygotes

decreased liver triglyceride level ( J:155432 )

• mice exhibit decreased liver triglyceride levels compared with Akt2^tm1Mbb Lep^ob homozygotes

growth/size/body

decreased body weight ( J:155432 )

• mice exhibit decreased body weight compared with Akt2^tm1Mbb Lep^ob homozygotes

• however, body composition was normal

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• mice exhibit decreased liver triglyceride levels compared with Akt2^tm1Mbb Lep^ob homozygotes

decreased liver weight ( J:155432 )

• mice exhibit decreased liver weight compared with Akt2^tm1Mbb Lep^ob homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24