All Phenotypes Akt2<tm1.2Mbb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akt2^tm1.2Mbb
targeted mutation 1.2, Morris J Birnbaum
MGI:4889113

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Tg(Alb1-cre)1Khk/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL	MGI:4889114
cn2	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Lep^ob/Lep^ob Tg(Alb1-cre)1Khk/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL	MGI:4889115

Allelic Composition	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Tg(Alb1-cre)1Khk/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.2Mbb mutation (1 available); any Akt2 mutation (51 available)
Tg(Alb1-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased liver triglyceride level ( J:155432 )

• in fed mice fed a Surwit high-fat diet at 1 and 4 months

growth/size/body

growth/size/body region phenotype ( J:155432 )

N	• mice exhibit normal body weight and susceptibility to diet-induced obesity

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• in fed mice fed a Surwit high-fat diet at 1 and 4 months

Allelic Composition	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Lep^ob/Lep^ob Tg(Alb1-cre)1Khk/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.2Mbb mutation (1 available); any Akt2 mutation (51 available)
Lep^ob mutation (5 available); any Lep mutation (19 available)
Tg(Alb1-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:155432 )

• fasted mice exhibit increased plasma glucose levels compared with Akt2^tm1Mbb Lep^ob homozygotes

abnormal lipid homeostasis ( J:155432 )

• mice exhibit reduced lipogenesis compared to in Akt2^tm1Mbb Lep^ob homozygotes

decreased liver triglyceride level ( J:155432 )

• mice exhibit decreased liver triglyceride levels compared with Akt2^tm1Mbb Lep^ob homozygotes

growth/size/body

decreased body weight ( J:155432 )

• mice exhibit decreased body weight compared with Akt2^tm1Mbb Lep^ob homozygotes

• however, body composition was normal

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• mice exhibit decreased liver triglyceride levels compared with Akt2^tm1Mbb Lep^ob homozygotes

decreased liver weight ( J:155432 )

• mice exhibit decreased liver weight compared with Akt2^tm1Mbb Lep^ob homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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