Phenotypes associated with this allele

• Allele Symbol: Cxcl12^tm1.1Ystz
• Allele Name: targeted mutation 1.1, Yi-Shiuan Tzeng
• Allele ID: MGI:4888352
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cxcl12^tm1.1Ystz/Cxcl12^tm1.2Ystz Tg(CAG-cre/Esr1*)5Amc/0	involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N	MGI:4888376

Genotype
MGI:4888376

cn1

• Allelic Composition: Cxcl12^tm1.1Ystz/Cxcl12^tm1.2Ystz; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased pro-B cell number ( J:168434 )

• in the bone marrow of tamoxifen-treated mice

increased neutrophil cell number ( J:168434 )

• tamoxifen-treated mice exhibit an increase in the percentage of circulating neutrophils compared with wild-type mice

decreased hematopoietic stem cell number ( J:168434 )

• tamoxifen-treated mice exhibit a reduction in long term hematopoietic stem cells compared with wild-type mice

increased hematopoietic stem cell number ( J:168434 )

• tamoxifen-treated mice exhibit an increase in LSK cells in the bone marrow and peripheral blood compared with wild-type mice

• tamoxifen-treated mice exhibit a 5-fold and 15-fold increase in LSK cells and colony-forming unit cells, respectively, in the spleen compared with wild-type mice

• tamoxifen-treated mice exhibit an increased in hematopoietic progenitors compared with wild-type mice

abnormal hematopoietic system physiology ( J:168434 )

• in a 5-fluorouracil myelosuppression model, tamoxifen-treated mice exhibit increased survival and faster hematologic recovery with less obvious bone marrow regeneration along the endosteal surface and ectopic regeneration in the perisinusoidal space compared with wild-type mice

abnormal hematopoietic stem cell physiology ( J:168434 )

• tamoxifen-treated mice exhibit hyperproliferation and reduced quiescence of hematopoietic stem/progenitor cells compared with wild-type mice

immune system

decreased pro-B cell number ( J:168434 )

• in the bone marrow of tamoxifen-treated mice

increased neutrophil cell number ( J:168434 )

• tamoxifen-treated mice exhibit an increase in the percentage of circulating neutrophils compared with wild-type mice