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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp521tm2Ngc
targeted mutation 2, Neal G Copeland
MGI:4887921
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Zfp521tm2Ngc/Zfp521+ Not Specified MGI:4887969
cx2
 		Runx2tm1Mjo/Runx2+
Zfp521tm2Ngc/Zfp521+ 		Not Specified MGI:4887971


Genotype
MGI:4887969
ht1
Allelic
Composition		 Zfp521tm2Ngc/Zfp521+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp521tm2Ngc mutation (0 available); any Zfp521 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
increased hyoid bone size ( J:167992 )
• the mineralized midpoint of the hyoid bone is increased length compared to in wild-type mice

skeleton
increased hyoid bone size ( J:167992 )
• the mineralized midpoint of the hyoid bone is increased length compared to in wild-type mice
abnormal clavicle morphology ( J:167992 )
• increased in length

growth/size/body
increased hyoid bone size ( J:167992 )
• the mineralized midpoint of the hyoid bone is increased length compared to in wild-type mice




Genotype
MGI:4887971
cx2
Allelic
Composition		 Runx2tm1Mjo/Runx2+
Zfp521tm2Ngc/Zfp521+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx2tm1Mjo mutation (0 available); any Runx2 mutation (44 available)
Zfp521tm2Ngc mutation (0 available); any Zfp521 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
decreased hyoid bone size ( J:167992 )
• the mineralized midpoint of the hyoid bone is decreased in length compared to in wild-type mice
• however, mineralization occurs unlike in Runx2tm1Mjo heterozygotes

skeleton
decreased hyoid bone size ( J:167992 )
• the mineralized midpoint of the hyoid bone is decreased in length compared to in wild-type mice
• however, mineralization occurs unlike in Runx2tm1Mjo heterozygotes
clavicle hypoplasia ( J:167992 )
• clavicle is smaller than in wild-type mice but not as severely reduced as in Runx2tm1Mjo heterozygotes

growth/size/body
decreased hyoid bone size ( J:167992 )
• the mineralized midpoint of the hyoid bone is decreased in length compared to in wild-type mice
• however, mineralization occurs unlike in Runx2tm1Mjo heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory