Phenotypes associated with this allele

• Allele Symbol: Gnas^tm2Jop
• Allele Name: targeted mutation 2, Jo Peters
• Allele ID: MGI:4887402
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gnas^tm2Jop/Gnas^+	involves: 129S/SvEv	MGI:5317111

Genotype
MGI:5317111

ht1

• Allelic Composition: Gnas^tm2Jop/Gnas⁺
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:182868 )

• 85% survival past weaning

growth/size/body

decreased birth weight ( J:182868 )

• 92% of control weight when paternally inherited

decreased lean body mass ( J:182868 )

• reduced lean body mass at 12 weeks when paternally inherited

• percentage of lean mass increased due to decrease in total fat

slow postnatal weight gain ( J:182868 )

• weight is 56% of normal controls at 2 weeks when paternally inherited

• weight is 75% of normal controls at 7-12 weeks

decreased body length ( J:182868 )

• at 12 weeks of age when paternally inherited

skeleton

short femur ( J:182868 )

• at 12 weeks of age when paternally inherited

decreased bone mineral density ( J:182868 )

• when paternally inherited

adipose tissue

decreased total body fat amount ( J:182868 )

• reduced total body fat at 12 weeks of age when paternally inherited

decreased percent body fat/body weight ( J:182868 )

• at 12 weeks of age when paternally inherited

behavior/neurological

behavior/neurological phenotype ( J:182868 )

N • suckling behavior normal

increased food intake ( J:182868 )

• food intake increases when paternally inherited

homeostasis/metabolism

decreased circulating leptin level ( J:182868 )

• reduced serum leptin levels and leptin mRNA levels in both white and brown adipose tissue

abnormal gas homeostasis ( J:182868 )

increased carbon dioxide production ( J:182868 )

• when paternally inherited

increased oxygen consumption ( J:182868 )

• when paternally inherited

increased basal metabolism ( J:182868 )

• when paternally inherited

limbs/digits/tail

short femur ( J:182868 )

• at 12 weeks of age when paternally inherited