Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Koss mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx3tm1Mlc mutation
(0 available);
any
Pbx3 mutation
(35 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
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craniofacial
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• cleft lip and/or palate
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• cleft lip and/or palate
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digestive/alimentary system
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• cleft lip and/or palate
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growth/size/body
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• cleft lip and/or palate
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• cleft lip and/or palate
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Koss mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
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craniofacial
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• cleft lip and/or palate
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• cleft lip and/or palate
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digestive/alimentary system
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• cleft lip and/or palate
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growth/size/body
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• cleft lip and/or palate
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• cleft lip and/or palate
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Pbx1tm1Koss mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
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craniofacial
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• the cleft lip phenotype observed in Pbx1tm1.1Koss/Pbx1tm1.1Koss Pbx2tm1Mlc/Pbx2+ Tg(Tcfap2a*-cre)1Will is rescued
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
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mortality/aging
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• mutants survive until birth
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craniofacial
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• all bones are present, but with minor defects
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• bones are connected by calcified tissues to form a trabecular basal plate, in contrast to being separated by cartilage as in wild-type embryos
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• ossifying center of the hyoid bone is missing at E18.5
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• only a fragment of the zygomatic process of the maxilla is found at E18.5
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• frontonasal prominence is narrowed, producing a protuberance with a beak-like appearance instead of a normal muzzle
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• hypoplasia of the lateral nasal prominence
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• the mandibular prominences fuse at the midline, but are severely underdeveloped at E11.5 and 12.5
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• hypoplasia of the medial nasal prominence
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• underdeveloped in mutants, consistent with hypoplasia of the medial and lateral nasal prominences
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• by E10.5 embyros exhibit a hypoplastic facial morphology, more characteristic of E9.5 embryos
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• part of the palatal processes of the maxilla are present in E18.5 embryos
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• all embryos display hypoplasia of the facial prominences
• at E9.0 facial prominences are comparable to wild-type; shortly after, facial prominences fail to grow and by E10.5 embyros exhibit a hypoplastic facial morphology, more characteristic of embryos at E9.5
• the groove overlying the lamina terminalis of forebrain which normally disappears around E10.5 is still present at E11.5
• increased cell death is observed at E10.5 in the developing facial region compared to controls
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skeleton
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• all bones are present, but with minor defects
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• bones are connected by calcified tissues to form a trabecular basal plate, in contrast to being separated by cartilage as in wild-type embryos
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• ossifying center of the hyoid bone is missing at E18.5
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• part of the palatal processes of the maxilla are present in E18.5 embryos
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• only a fragment of the zygomatic process of the maxilla is found at E18.5
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hearing/vestibular/ear
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• most of the ectotympanic bone is missing in mutants at E18.5
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vision/eye
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• some defects in lens formation are suggested
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• at E10.5 the optic eminence is reduced, as well as the corneal endoderm
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• the eyelids fail to form during development
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digestive/alimentary system
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• part of the palatal processes of the maxilla are present in E18.5 embryos
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respiratory system
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• underdeveloped in mutants, consistent with hypoplasia of the medial and lateral nasal prominences
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taste/olfaction
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• underdeveloped in mutants, consistent with hypoplasia of the medial and lateral nasal prominences
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growth/size/body
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• by E10.5 embyros exhibit a hypoplastic facial morphology, more characteristic of E9.5 embryos
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• part of the palatal processes of the maxilla are present in E18.5 embryos
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• all embryos display hypoplasia of the facial prominences
• at E9.0 facial prominences are comparable to wild-type; shortly after, facial prominences fail to grow and by E10.5 embyros exhibit a hypoplastic facial morphology, more characteristic of embryos at E9.5
• the groove overlying the lamina terminalis of forebrain which normally disappears around E10.5 is still present at E11.5
• increased cell death is observed at E10.5 in the developing facial region compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esrp1tm1.1Rpc mutation
(1 available);
any
Esrp1 mutation
(19 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
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craniofacial
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• underdeveloped with a poor connection to the maxilla and extend out in front of the face
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• bilateral cleft lip/palate at E18.5
• failure of the lip processes to come together to form a midline philtrum
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• similar to palatine bones
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• hypoplastic and located to the side
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• bilateral cleft of the primary palate at E18.5
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• bilateral cleft lip/palate at E18.5
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skeleton
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• similar to palatine bones
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• underdeveloped with a poor connection to the maxilla and extend out in front of the face
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• hypoplastic and located to the side
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digestive/alimentary system
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• similar to palatine bones
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• hypoplastic and located to the side
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• bilateral cleft of the primary palate at E18.5
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• bilateral cleft lip/palate at E18.5
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growth/size/body
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• bilateral cleft lip/palate at E18.5
• failure of the lip processes to come together to form a midline philtrum
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• similar to palatine bones
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• hypoplastic and located to the side
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• bilateral cleft of the primary palate at E18.5
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• bilateral cleft lip/palate at E18.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnd1tm1Abre mutation
(0 available);
any
Ctnnd1 mutation
(122 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
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craniofacial
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• at E11.5, some non-cleft presenting embryos show a delay in the medial growth of the maxillary prominences
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• approximately half of the non-cleft presenting embryos show obvious nasal airway asymmetry
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• at E10.5-E18.5, ~47% of embryos exhibit a spectrum of overt clefts including: unilateral cleft lip only; unilateral cleft lip and cleft palate; bilateral cleft lip and cleft palate; or cleft secondary palate only
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• unilateral cleft lip only, unilateral cleft lip and cleft palate, and bilateral cleft lip and cleft palate are observed
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• unilateral cleft lip and cleft palate as well as bilateral cleft lip and cleft palate are observed
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• cleft secondary palate only is also observed
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• non-cleft presenting embryos exhibit dysmorphic nares
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• non-cleft presenting embryos exhibit dysmorphic nasal tips
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growth/size/body
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• approximately half of the non-cleft presenting embryos show obvious nasal airway asymmetry
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• at E10.5-E18.5, ~47% of embryos exhibit a spectrum of overt clefts including: unilateral cleft lip only; unilateral cleft lip and cleft palate; bilateral cleft lip and cleft palate; or cleft secondary palate only
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• unilateral cleft lip only, unilateral cleft lip and cleft palate, and bilateral cleft lip and cleft palate are observed
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• unilateral cleft lip and cleft palate as well as bilateral cleft lip and cleft palate are observed
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• cleft secondary palate only is also observed
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• non-cleft presenting embryos exhibit dysmorphic nares
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• non-cleft presenting embryos exhibit dysmorphic nasal tips
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digestive/alimentary system
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• unilateral cleft lip and cleft palate as well as bilateral cleft lip and cleft palate are observed
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• cleft secondary palate only is also observed
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respiratory system
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• non-cleft presenting embryos exhibit dysmorphic nares
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• non-cleft presenting embryos exhibit dysmorphic nasal tips
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnd1tm1Abre mutation
(0 available);
any
Ctnnd1 mutation
(122 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
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craniofacial
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• at E11.5, a delay in the medial growth of the maxillary prominences is observed
• however, no overt clefts are identified
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
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mortality/aging
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• most embryos die between E12.5 and 16.5, likely due to vasculature defects
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• most embryos die between E12.5 and 16.5, likely due to vasculature defects
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craniofacial
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• in some mutants this is turned downward and in others, is duplicated on the interior aspect
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• mandibular prominences is increased in size, resulting in lack of proper lower jaw formation or fusion and forming a widened oral cavity
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• maxillary prominence is increased in size, resulting in lack of proper upper jaw formation or fusion and forming a widened oral cavity
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• the nasal process does not show controlled directional growth that results in formation of a normal nasal pit
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• most mutants lack any recognizable facial features; some embryos have discernible features but these show severe defects
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• embryos do not exhibit recognizable facial features except for a widened oral cavity
• facial development is normal at E9.0, but soon after facial prominences enlarge more rapidly than wild-type
• no significant changes in cell death or proliferation are detected at E10.5
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• at E12.5, mutants lack external (visible) ears
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skeleton
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• in some mutants this is turned downward and in others, is duplicated on the interior aspect
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• cartilages in the head such as the parachordal plate and cartilages of the ear are grossly malformed
• nasal cartilages are wider and misshapen
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• mutants have extensive ectopic cartilages in the head region resulting in cartilage fusions and malformations
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hearing/vestibular/ear
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• at E12.5, mutants lack external (visible) ears
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vision/eye
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• at E12.5, mutants lack external eyes although rudimentary eyes are found internalized
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integument
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• at E12.5, mutants lack vibrissae
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growth/size/body
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• most mutants lack any recognizable facial features; some embryos have discernible features but these show severe defects
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• embryos do not exhibit recognizable facial features except for a widened oral cavity
• facial development is normal at E9.0, but soon after facial prominences enlarge more rapidly than wild-type
• no significant changes in cell death or proliferation are detected at E10.5
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• at E12.5, mutants lack external (visible) ears
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Analysis Tools